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    MUTE basic helix-loop-helix (bHLH) DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819785, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MUTE
    Official Full Name
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    Primary source
    TAIR:AT3G06120
    Locus tag
    AT3G06120
    See related
    Araport:AT3G06120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28L1.6; F28L1_6
    Summary
    Encodes a basic helix-loop-helix (bHLH) protein that controls meristemoid differentiation during stomatal development. In the absence of MUTE, meristemoids abort after excessive asymmetric divisions and fail to differentiate stomata. MUTE expression in the meristemoid is required for SLGCs differentiation as pavement cells. Epidermal cells lose their competence to respond to MUTE overexpression during cotyledon development.
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    Genomic context

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    See MUTE in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (1846442..1848259)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene MAPK phosphatase 2 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell Cycle Dynamics during Stomatal Development: Window of MUTE Action and Ramification of Its Loss-of-Function on an Uncommitted Precursor. Zuch DT, et al. Plant Cell Physiol, 2023 Mar 15. PMID 36609867, Free PMC Article
    2. MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata. Han SK, et al. Dev Cell, 2018 May 7. PMID 29738710
    3. The bHLH protein, MUTE, controls differentiation of stomata and the hydathode pore in Arabidopsis. Pillitteri LJ, et al. Plant Cell Physiol, 2008 Jun. PMID 18450784
    4. Termination of asymmetric cell division and differentiation of stomata. Pillitteri LJ, et al. Nature, 2007 Feb 1. PMID 17183267
    5. Transcription factor control of asymmetric cell divisions that establish the stomatal lineage. MacAlister CA, et al. Nature, 2007 Feb 1. PMID 17183265

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell Cycle Dynamics during Stomatal Development: Window of MUTE Action and Ramification of Its Loss-of-Function on an Uncommitted Precursor.
      Title: Cell Cycle Dynamics during Stomatal Development: Window of MUTE Action and Ramification of Its Loss-of-Function on an Uncommitted Precursor.
    2. regulatory network initiated by MUTE represents an incoherent type 1 feed-forward loop
      Title: MUTE Directly Orchestrates Cell-State Switch and the Single Symmetric Division to Create Stomata.
    3. Here, the authors report that EPF1 and its primary receptor ERECTA-LIKE1 (ERL1) target MUTE, a transcription factor specifying the proliferation-to-differentiation switch within the stomatal cell lineages. In turn, MUTE directly induces ERL1.
      Title: Autocrine regulation of stomatal differentiation potential by EPF1 and ERECTA-LIKE1 ligand-receptor signaling.
    4. Timely MUTE expression is essential to prevent stomatal fate in SLGCs and to promote their differentiation as pavement cells.
      Title: Timely expression of the Arabidopsis stoma-fate master regulator MUTE is required for specification of other epidermal cell types.
    5. We report that MUTE controls downstream events directing stomatal differentiation and that MUTE is required for the production of the structure evolutionarily related to stomata, the hydathode pore.
      Title: The bHLH protein, MUTE, controls differentiation of stomata and the hydathode pore in Arabidopsis.
    6. regulates cell-cell interaction involved in stomatal development.
      Title: [Three bHLH master regulators and cell-cell interaction involved in stomatal development].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111487.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in guard cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within plant epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    basic helix-loop-helix (bHLH) DNA-binding superfamily protein
    NP_187263.1
    • MUTE (MUTE); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT3G24140.1); Has 1269 Blast hits to 1254 proteins in 66 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 1269; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1846442..1848259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111487.3 → NP_187263.1  basic helix-loop-helix (bHLH) DNA-binding superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187263.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MEU5, Q9M8K6
      UniProtKB/TrEMBL
      A0A178VCY0, A0A5S9X9M8, A0A7G2EMM3
      Conserved Domains (1) summary
      cd11448
      Location:1 → 74
      bHLH_AtFAMA_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein FAMA and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8K6.1

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