Tenm2 teneurin transmembrane protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Tenm2provided by RGD
Full Name: teneurin transmembrane protein 2provided by RGD
Primary source: RGD:727907
See related: EnsemblRapid:ENSRNOG00000027341 AllianceGenome:RGD:727907
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Odz2; Lasso
Summary: Enables cell adhesion molecule binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of filopodium assembly; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in dendritic spine and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 70.7), Adrenal (RPKM 8.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (20984710..22121001, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (20480662..21706415, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (20846091..21791771, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
Title: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.

Submit: New GeneRIF Correction

General gene information

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Markers

AW529537 (e-PCR)
- UniSTS:261143

BE096193 (e-PCR)
- UniSTS:243999

RH144521 (e-PCR)
- UniSTS:233766

D3Bwg1534e (e-PCR), detects polymorphism
- UniSTS:142384

D10Mit5 (e-PCR), detects polymorphism
- UniSTS:119427

d10rat75 (e-PCR)
- UniSTS:120731

D10Rat42 (e-PCR)
- UniSTS:118183

AI501498 (e-PCR)
- UniSTS:226231

AU049925 (e-PCR)
- UniSTS:146367

BE102452 (e-PCR)
- UniSTS:244192

D11Mit232 (e-PCR), detects polymorphism
- UniSTS:126433

Odz2 (e-PCR), detects polymorphism
- UniSTS:507881

RH138576 (e-PCR)
- UniSTS:220663

D10Rat179 (e-PCR), detects polymorphism
- UniSTS:226297

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex	IEA Inferred from Electronic Annotation more info
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in PML body	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: teneurin-2

Names: neurestin; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2; ten-2; ten-m2; tenascin-M2; teneurin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020088.1 → NP_064473.1 teneurin-2

See identical proteins and their annotated locations for NP_064473.1

Status: PROVISIONAL

Source sequence(s)

AF086607

UniProtKB/TrEMBL

A6HDJ4

Related

ENSRNOP00000109718.1, ENSRNOT00000171102.1

Conserved Domains (11) summary

COG3209
Location:1680 → 2473

RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]

cd00054
Location:671 → 700

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd05819
Location:1231 → 1270

NHL; NHL repeat [structural motif]

TIGR03696
Location:2382 → 2459

Rhs_assc_core; RHS repeat-associated core domain

pfam05593
Location:1673 → 1711

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam07974
Location:580 → 602

EGF_2; EGF-like domain

pfam15636
Location:2683 → 2758

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1231 → 1561

NHL; NHL repeat unit of beta-propeller proteins

cl19567
Location:755 → 796

DSL; Delta serrate ligand

cl21470
Location:923 → 1007

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

20984710..22121001 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085070.2 → XP_038940998.1 teneurin-2 isoform X5

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Related

ENSRNOP00000108300.1, ENSRNOT00000146782.1

Conserved Domains (8) summary

COG3209
Location:1885 → 2371

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1170 → 1209

NHL; NHL repeat [structural motif]

TIGR03696
Location:2321 → 2398

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1170 → 1500

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1612 → 1648

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 304

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2620 → 2697

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:500 → 815

exchanger_TraA; outer membrane exchange protein TraA
XM_063268320.1 → XP_063124390.1 teneurin-2 isoform X7

Related

ENSRNOP00000112023.1, ENSRNOT00000132901.1
XM_039085069.2 → XP_038940997.1 teneurin-2 isoform X4

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1907 → 2393

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1199 → 1227

NHL; NHL repeat [structural motif]

TIGR03696
Location:2343 → 2420

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1199 → 1522

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1634 → 1670

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2642 → 2719

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:529 → 844

exchanger_TraA; outer membrane exchange protein TraA
XM_039085068.2 → XP_038940996.1 teneurin-2 isoform X3

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1914 → 2400

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1199 → 1238

NHL; NHL repeat [structural motif]

TIGR03696
Location:2350 → 2427

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1199 → 1529

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1641 → 1677

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2649 → 2726

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:529 → 844

exchanger_TraA; outer membrane exchange protein TraA
XM_039085071.2 → XP_038940999.1 teneurin-2 isoform X6

UniProtKB/TrEMBL

A0A8I5Y1H9, A6HDJ4

Related

ENSRNOP00000077386.1, ENSRNOT00000097791.2

Conserved Domains (9) summary

COG3209
Location:1884 → 2370

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1169 → 1208

NHL; NHL repeat [structural motif]

TIGR03696
Location:2320 → 2397

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1169 → 1499

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1611 → 1647

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2619 → 2696

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033662
Location:772 → 802

acid_disulf_rpt; acidic double-disulfide repeat

NF033759
Location:570 → 808

exchanger_TraA; outer membrane exchange protein TraA
XM_039085066.2 → XP_038940994.1 teneurin-2 isoform X2

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Related

ENSRNOP00000099251.1, ENSRNOT00000173444.1

Conserved Domains (8) summary

COG3209
Location:1948 → 2434

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1240 → 1268

NHL; NHL repeat [structural motif]

TIGR03696
Location:2384 → 2461

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1240 → 1563

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1675 → 1711

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2683 → 2760

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:570 → 885

exchanger_TraA; outer membrane exchange protein TraA
XM_039085063.2 → XP_038940991.1 teneurin-2 isoform X1

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

UniProtKB/TrEMBL

A0A096P6L6

Related

ENSRNOP00000011922.8, ENSRNOT00000011922.10

Conserved Domains (8) summary

COG3209
Location:1955 → 2441

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1240 → 1279

NHL; NHL repeat [structural motif]

TIGR03696
Location:2391 → 2468

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1240 → 1570

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1682 → 1718

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 374

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2690 → 2767

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:570 → 885

exchanger_TraA; outer membrane exchange protein TraA
XM_063268319.1 → XP_063124389.1 teneurin-2 isoform X1

UniProtKB/TrEMBL

A0A096P6L6
XM_039085076.2 → XP_038941004.1 teneurin-2 isoform X12

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1733 → 2219

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1018 → 1057

NHL; NHL repeat [structural motif]

TIGR03696
Location:2169 → 2246

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1018 → 1348

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1460 → 1496

RHS_repeat; RHS Repeat

pfam06484
Location:14 → 152

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2468 → 2545

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:348 → 663

exchanger_TraA; outer membrane exchange protein TraA
XM_063268321.1 → XP_063124391.1 teneurin-2 isoform X10
XM_063268322.1 → XP_063124392.1 teneurin-2 isoform X13
XM_039085072.2 → XP_038941000.1 teneurin-2 isoform X8

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1803 → 2289

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1088 → 1127

NHL; NHL repeat [structural motif]

TIGR03696
Location:2239 → 2316

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1088 → 1418

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1530 → 1566

RHS_repeat; RHS Repeat

pfam06484
Location:10 → 222

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2538 → 2615

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:418 → 733

exchanger_TraA; outer membrane exchange protein TraA
XM_039085075.2 → XP_038941003.1 teneurin-2 isoform X11

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1758 → 2244

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1043 → 1082

NHL; NHL repeat [structural motif]

TIGR03696
Location:2194 → 2271

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1043 → 1373

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1485 → 1521

RHS_repeat; RHS Repeat

pfam06484
Location:1 → 177

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2493 → 2570

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:373 → 688

exchanger_TraA; outer membrane exchange protein TraA
XM_039085074.2 → XP_038941002.1 teneurin-2 isoform X9

UniProtKB/Swiss-Prot

Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2

Conserved Domains (8) summary

COG3209
Location:1793 → 2279

RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]

cd05819
Location:1078 → 1117

NHL; NHL repeat [structural motif]

TIGR03696
Location:2229 → 2306

Rhs_assc_core; RHS repeat-associated core domain

cl18310
Location:1078 → 1408

NHL; NHL repeat unit of beta-propeller proteins

pfam05593
Location:1520 → 1556

RHS_repeat; RHS Repeat

pfam06484
Location:4 → 212

Ten_N; Teneurin Intracellular Region

pfam15636
Location:2528 → 2605

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033759
Location:408 → 723

exchanger_TraA; outer membrane exchange protein TraA