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    Dop1a DOP1 leucine zipper like protein A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dop1aprovided by RGD
    Official Full Name
    DOP1 leucine zipper like protein Aprovided by RGD
    Primary source
    RGD:1305534
    See related
    EnsemblRapid:ENSRNOG00000022847 AllianceGenome:RGD:1305534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dopey1; RGD1305534
    Summary
    Predicted to be involved in Golgi to endosome transport. Located in Golgi-associated vesicle. Orthologous to human DOP1A (DOP1 leucine zipper like protein A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 168.0), Brain (RPKM 124.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dop1a in Genome Data Viewer
    Location:
    8q31
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (96295302..96397951)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (87415266..87517935)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94122733..94225131)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480084 Neighboring gene ubiquitin protein ligase E3D Neighboring gene stathmin-like Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The VF rat with abnormal myelinogenesis has a mutation in Dopey1. Tanaka M, et al. Glia, 2014 Sep. PMID 24863653
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein dopey-1
    Names
    dopey family member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427274.1 → NP_001414203.1  protein dopey-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4A0Y2
      Related
      ENSRNOP00000083794.2, ENSRNOT00000114743.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      96295302..96397951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596105.3 → XP_017451594.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      D4A0Y2

    2. XM_017596108.3 → XP_017451597.1  protein dopey-1 isoform X3

      UniProtKB/TrEMBL
      D4A0Y2
      Related
      ENSRNOP00000014783.8, ENSRNOT00000014783.10

    3. XM_017596107.3 → XP_017451596.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      D4A0Y2

    4. XM_039082549.2 → XP_038938477.1  protein dopey-1 isoform X5

      UniProtKB/TrEMBL
      D4A0Y2
      Related
      ENSRNOP00000102517.1, ENSRNOT00000143181.1
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 297
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2078 → 2314
      Dopey_N; Dopey, N-terminal

    5. XM_006243503.5 → XP_006243565.1  protein dopey-1 isoform X4

      See identical proteins and their annotated locations for XP_006243565.1

      UniProtKB/TrEMBL
      A0A8I6A0N6, D4A0Y2
      Conserved Domains (2) summary
      pfam04118
      Location:13 → 300
      Dopey_N; Dopey, N-terminal
      cl04407
      Location:2079 → 2315
      Dopey_N; Dopey, N-terminal

    6. XM_063265561.1 → XP_063121631.1  protein dopey-1 isoform X2

      UniProtKB/TrEMBL
      D4A0Y2

    7. XM_017596106.3 → XP_017451595.1  protein dopey-1 isoform X1

      UniProtKB/TrEMBL
      D4A0Y2

    8. XM_039082550.2 → XP_038938478.1  protein dopey-1 isoform X6

      Conserved Domains (1) summary
      cl04407
      Location:1525 → 1761
      Dopey_N; Dopey, N-terminal

    RNA

    1. XR_005488357.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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