Efcab7 EF-hand calcium binding domain 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Efcab7provided by RGD
Official Full Name: EF-hand calcium binding domain 7provided by RGD
Primary source: RGD:1561825
See related: EnsemblRapid:ENSRNOG00000009782 AllianceGenome:RGD:1561825
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561825
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including positive regulation of protein localization; positive regulation of transcription by RNA polymerase II; and protein localization to motile cilium. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. Predicted to be active in ciliary membrane. Orthologous to human EFCAB7 (EF-hand calcium binding domain 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 71.5), Lung (RPKM 52.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (119640841..119691566)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (114525403..114576130)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (118673835..118724581)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to ciliary membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein localization to motile cilium	ISO Inferred from Sequence Orthology more info
involved_in regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EF-hand calcium-binding domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191866.1 → NP_001178795.1 EF-hand calcium-binding domain-containing protein 7

See identical proteins and their annotated locations for NP_001178795.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6A396, D3ZZK0

Related

ENSRNOP00000076772.2, ENSRNOT00000106347.2

Conserved Domains (2) summary

COG5126
Location:16 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cl08302
Location:407 → 467

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

119640841..119691566

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763885.4 → XP_008762107.1 EF-hand calcium-binding domain-containing protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0R4, A0A8I6A396

Conserved Domains (3) summary

COG5126
Location:35 → 188

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:125 → 185

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl08302
Location:426 → 486

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_039110291.2 → XP_038966219.1 EF-hand calcium-binding domain-containing protein 7 isoform X4

UniProtKB/TrEMBL

A6JRM4

Conserved Domains (1) summary

COG5126
Location:35 → 188

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
XM_008763886.3 → XP_008762108.1 EF-hand calcium-binding domain-containing protein 7 isoform X2

See identical proteins and their annotated locations for XP_008762108.1

UniProtKB/TrEMBL

A0A8I6A396, D3ZZK0

Conserved Domains (2) summary

COG5126
Location:16 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cl08302
Location:407 → 467

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_039110289.1 → XP_038966217.1 EF-hand calcium-binding domain-containing protein 7 isoform X2

UniProtKB/TrEMBL

A0A8I6A396, D3ZZK0

Conserved Domains (2) summary

COG5126
Location:16 → 169

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cl08302
Location:407 → 467

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_039110290.2 → XP_038966218.1 EF-hand calcium-binding domain-containing protein 7 isoform X3

UniProtKB/TrEMBL

A0A8I6A396

Conserved Domains (1) summary

cl08302
Location:270 → 330

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...