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    G2e3 G2/M-phase specific E3 ubiquitin protein ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    G2e3provided by RGD
    Official Full Name
    G2/M-phase specific E3 ubiquitin protein ligaseprovided by RGD
    Primary source
    RGD:1310263
    See related
    EnsemblRapid:ENSRNOG00000004232 AllianceGenome:RGD:1310263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310263
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in nucleus. Orthologous to human G2E3 (G2/M-phase specific E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 99.4), Spleen (RPKM 73.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See G2e3 in Genome Data Viewer
    Location:
    6q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (74498801..74530703)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (68763847..68795305)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (72092148..72123878)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479382 Neighboring gene uncharacterized LOC134479383 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 3 Neighboring gene sec1 family domain containing 1 Neighboring gene uncharacterized LOC134479180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. G2E3 is a dual function ubiquitin ligase required for early embryonic development. Brooks WS, et al. J Biol Chem, 2008 Aug 8. PMID 18511420, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G2/M phase-specific E3 ubiquitin-protein ligase
    Names
    G2/M-phase specific E3 ubiquitin ligase
    NP_001100196.1
    XP_006240140.1
    XP_006240141.1
    XP_017449571.1
    XP_017449572.1
    XP_063117736.1
    XP_063117737.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106726.2 → NP_001100196.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

      See identical proteins and their annotated locations for NP_001100196.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZML5, A6HBG8, D3ZC11
      Related
      ENSRNOP00000005670.6, ENSRNOT00000005670.9
      Conserved Domains (3) summary
      cd15496
      Location:232 → 285
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:14 → 127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl27008
      Location:365 → 688
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. NM_001434262.1 → NP_001421191.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZML5, A6HBG8, D3ZC11

    3. NM_001434263.1 → NP_001421192.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZML5, A6HBG8, D3ZC11

    4. NM_001434264.1 → NP_001421193.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZML5

    5. NM_001434265.1 → NP_001421194.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZML5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      74498801..74530703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261666.1 → XP_063117736.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZML5, A6HBG8, D3ZC11

    2. XM_006240079.5 → XP_006240141.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

      Conserved Domains (3) summary
      cd15496
      Location:232 → 285
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:14 → 127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl27008
      Location:365 → 688
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    3. XM_017594083.3 → XP_017449572.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZML5
      Related
      ENSRNOP00000111434.1, ENSRNOT00000122091.1

    4. XM_063261667.1 → XP_063117737.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    5. XM_006240078.5 → XP_006240140.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

      Conserved Domains (3) summary
      cd15496
      Location:232 → 285
      PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cd15669
      Location:14 → 127
      ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
      cl27008
      Location:365 → 688
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    6. XM_017594082.3 → XP_017449571.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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