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    Pcdha12 protocadherin alpha 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcdha12provided by RGD
    Official Full Name
    protocadherin alpha 12provided by RGD
    Primary source
    RGD:620750
    See related
    AllianceGenome:RGD:620750
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rCNRv12
    Summary
    Predicted to be located in membrane. Orthologous to human PCDHA12 (protocadherin alpha 12). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
    Expression
    Biased expression in Brain (RPKM 148.0), Lung (RPKM 101.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcdha12 in Genome Data Viewer
    Location:
    18p11

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic sequence and organization of the family of CNR/Pcdhalpha genes in rat. Yanase H, et al. Genomics, 2004 Apr. PMID 15028293
    2. Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Zou C, et al. Neuroscience, 2007 Jan 19. PMID 17110050
    3. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, et al. Endocrinology, 2000 Feb. PMID 10650949
    4. Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha. Murata Y, et al. J Biol Chem, 2004 Nov 19. PMID 15347688
    5. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, et al. Genome Res, 2004 Jan. PMID 14672974, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin alpha 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053940.1 → NP_446392.1  protocadherin alpha 12 precursor

      See identical proteins and their annotated locations for NP_446392.1

      Status: PROVISIONAL

      Source sequence(s)
      AB113395
      UniProtKB/TrEMBL
      Q593Y1, Q767I0
      Conserved Domains (3) summary
      cd11304
      Location:246 → 345
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:30 → 111
      Cadherin_2; Cadherin-like
      pfam15974
      Location:799 → 942
      Cadherin_tail; Cadherin C-terminal cytoplasmic tail, catenin-binding region
    Nucleotide Protein Strain
    Heading Accession and Version

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