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    MYB98 myb domain protein 98 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827611, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB98
    Official Full Name
    myb domain protein 98
    Primary source
    TAIR:AT4G18770
    Locus tag
    AT4G18770
    See related
    Araport:AT4G18770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMYB98; F28A21.180; F28A21_180; myb domain protein 98
    Summary
    MYB98 is a member of the R2R3-MYB gene family, the members of which likely encode transcription factors. Within an ovule, MYB98 is expressed exclusively in the synergid cells, and mutations in this gene affect the female gametophyte specifically. myb98 female gametophytes are affected in two unique features of the synergid cell, pollen tube guidance and the filiform apparatus, but are otherwise normal. This suggests that MYB98 controls the development of specific features within the synergid cell during female gametophyte development. MYB98 also is expressed in trichomes and endosperm. Homozygous myb98 mutants exhibit no sporophytic defects, including trichome and endosperm defects.
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    Genomic context

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    See MYB98 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (10311030..10313104)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene receptor like protein 51 Neighboring gene cellulose synthase family protein Neighboring gene ncRNA Neighboring gene NRAMP metal ion transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic Ca2+ changes dynamically during the interaction of the pollen tube with synergid cells. Iwano M, et al. Development, 2012 Nov. PMID 23093426
    2. The MYB98 subcircuit of the synergid gene regulatory network includes genes directly and indirectly regulated by MYB98. Punwani JA, et al. Plant J, 2008 Aug. PMID 18410484
    3. Genome-wide expression profiling of the Arabidopsis female gametophyte identifies families of small, secreted proteins. Jones-Rhoades MW, et al. PLoS Genet, 2007 Oct. PMID 17937500, Free PMC Article
    4. MYB98 is required for pollen tube guidance and synergid cell differentiation in Arabidopsis. Kasahara RD, et al. Plant Cell, 2005 Nov. PMID 16214903, Free PMC Article
    5. MYB98 positively regulates a battery of synergid-expressed genes encoding filiform apparatus localized proteins. Punwani JA, et al. Plant Cell, 2007 Aug. PMID 17693534, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 11 CRP3700 genes are shown to be regulated by a common cis-element, GTAACNT, and a multimer of this sequence confers MYB98-dependent synergid expression.
      Title: The MYB98 subcircuit of the synergid gene regulatory network includes genes directly and indirectly regulated by MYB98.
    2. These data suggest that MYB98 functions as a transcriptional regulator in the synergid cells and activates the expression of genes required for pollen tube guidance and filiform apparatus formation.
      Title: MYB98 positively regulates a battery of synergid-expressed genes encoding filiform apparatus localized proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117993.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen tube guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of embryo sac central cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synergid differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synergid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synergid differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myb domain protein 98
    NP_193612.1
    • myb domain protein 98 (MYB98); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: myb domain protein 118 (TAIR:AT3G27785.1); Has 10125 Blast hits to 8427 proteins in 562 species: Archae - 0; Bacteria - 3; Metazoa - 1026; Fungi - 830; Plants - 5955; Viruses - 3; Other Eukaryotes - 2308 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10311030..10313104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117993.3 → NP_193612.1  myb domain protein 98 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0MF81, Q3HSE6, Q9S7L2
      UniProtKB/TrEMBL
      A0A5S9XTR7, A0A654FQL8
      Conserved Domains (3) summary
      smart00717
      Location:217 → 265
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:269 → 311
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:220 → 280
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7L2.1

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