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    CMT2 chromomethylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827640, updated on 14-Nov-2024

    Summary

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    Official Symbol
    CMT2
    Official Full Name
    chromomethylase 2
    Primary source
    TAIR:AT4G19020
    Locus tag
    AT4G19020
    See related
    Araport:AT4G19020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    chromomethylase 2; F13C5.190; F13C5_190
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    Genomic context

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    See CMT2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    23
    Sequence:
    Chromosome: 4; NC_003075.7 (10414428..10421265)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene E2F/DP family winged-helix DNA-binding domain-containing protein Neighboring gene Proteasome component (PCI) domain protein Neighboring gene AMP-dependent synthetase and ligase family protein Neighboring gene NOD26-like major intrinsic protein 1 Neighboring gene low-molecular-weight cysteine-rich 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality. Shen X, et al. PLoS Genet, 2014 Dec. PMID 25503602, Free PMC Article
    2. DNA methyltransferase CHROMOMETHYLASE3 prevents ONSEN transposon silencing under heat stress. Nozawa K, et al. PLoS Genet, 2021 Aug. PMID 34411103, Free PMC Article
    3. Contiguous and stochastic CHH methylation patterns of plant DRM2 and CMT2 revealed by single-read methylome analysis. Harris KD, et al. Genome Biol, 2020 Aug 6. PMID 32762764, Free PMC Article
    4. Identification of Arabidopsis SUMO-interacting proteins that regulate chromatin activity and developmental transitions. Elrouby N, et al. Proc Natl Acad Sci U S A, 2013 Dec 3. PMID 24255109, Free PMC Article
    5. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA methyltransferase CHROMOMETHYLASE3 prevents ONSEN transposon silencing under heat stress.
      Title: DNA methyltransferase CHROMOMETHYLASE3 prevents ONSEN transposon silencing under heat stress.
    2. Contiguous and stochastic CHH methylation patterns of plant DRM2 and CMT2 revealed by single-read methylome analysis.
      Title: Contiguous and stochastic CHH methylation patterns of plant DRM2 and CMT2 revealed by single-read methylome analysis.
    3. There is a natural variation in CMT2 and epigenetic changes to temperature adaptation; plants with a defective CMT2 gene tolerate heat-stress better than plants with a functional gene
      Title: Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341318.1
    NM_118020.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA (cytosine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA (cytosine-5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables SUMO binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    chromomethylase 2
    NP_193637.2
    • chromomethylase 2 (CMT2); FUNCTIONS IN: chromatin binding, DNA binding; INVOLVED IN: chromatin assembly or disassembly, DNA methylation; LOCATED IN: chromatin, nucleus; CONTAINS InterPro DOMAIN/s: DNA methylase, C-5 cytosine-specific (InterPro:IPR001525), Chromo domain-like (InterPro:IPR016197), Bromo adjacent homology (BAH) domain (InterPro:IPR001025), Chromo domain (InterPro:IPR000953); BEST Arabidopsis thaliana protein match is: chromomethylase 3 (TAIR:AT1G69770.1); Has 5135 Blast hits to 4403 proteins in 1000 species: Archae - 207; Bacteria - 2602; Metazoa - 790; Fungi - 215; Plants - 463; Viruses - 25; Other Eukaryotes - 833 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10414428..10421265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118020.5 → NP_193637.2  chromomethylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193637.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49415, Q94F87
      UniProtKB/TrEMBL
      A0A5S9XUG1
      Conserved Domains (3) summary
      COG0270
      Location:729 → 1267
      Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
      cd00024
      Location:835 → 890
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd04716
      Location:577 → 694
      BAH_plantDCM_I; BAH, or Bromo Adjacent Homology domain, first copy present in DNA (Cytosine-5)-methyltransferases (DCM) from plants. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects ...

    2. NM_001341318.1 → NP_001329724.1  chromomethylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8N3, A0A5S9XUG1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94F87.3

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