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    Pask PAS domain containing serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301617, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Paskprovided by RGD
    Official Full Name
    PAS domain containing serine/threonine kinaseprovided by RGD
    Primary source
    RGD:1306146
    See related
    EnsemblRapid:ENSRNOG00000016888 AllianceGenome:RGD:1306146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of glycogen biosynthetic process; protein autophosphorylation; and regulation of glucagon secretion. Predicted to be active in cytosol and nucleus. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 82.4), Thymus (RPKM 45.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pask in Genome Data Viewer
    Location:
    9q36
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101291673..101333288, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93844275..93886036, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100450595..100479719, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-associated domain-containing protein 1 pseudogene Neighboring gene mitochondrial transcription termination factor 4 Neighboring gene protein NYNRIN-like Neighboring gene protein phosphatase 1, regulatory subunit 7 Neighboring gene U6 spliceosomal RNA Neighboring gene anoctamin 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Liu YQ, et al. J Plast Reconstr Aesthet Surg, 2015 Jul. PMID 26003800
    2. PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors. Hurtado-Carneiro V, et al. Mol Neurobiol, 2013 Dec. PMID 23765195
    3. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. Kikani CK, et al. J Biol Chem, 2010 Dec 24. PMID 20943661, Free PMC Article
    4. Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Fontés G, et al. Diabetes, 2009 Sep. PMID 19502418, Free PMC Article
    5. Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. Soliz J, et al. Am J Physiol Regul Integr Comp Physiol, 2008 Aug. PMID 18509100

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hydrogen-rich saline ameliorated inflammatory infiltration and decreased cell apoptosis;tissues with a high expression of Bcl-2 and a low expression of pASK-1, pJNK, and Bax, a larger survival area and a high level of blood perfusion.
      Title: Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway.
    2. WNK 1, 3, 4, OSR1, and SPAK signaling system known to play a role in regulating the phosphorylation status, and hence activity of the CCCs in other tissues, is also present in the rat and human lenses.
      Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
    3. PASK is a key kinase in GLP-1 actions and exerts a coordinated response with the other metabolic sensors.
      Title: PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors.
    4. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells.
      Title: Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.
    5. Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion
      Title: Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.
    6. PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes.
      Title: Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.
    7. PASK is a novel mediator of glucolipotoxicity on the insulin gene in pancreatic beta-cells
      Title: Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
    8. PASK acts in a cell-autonomous manner to maintain cellular energy homeostasis and is a potential therapeutic target for metabolic disease
      Title: PAS kinase is required for normal cellular energy balance.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93882

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PAS domain-containing serine/threonine-protein kinase
    NP_001009362.1
    XP_038939347.1
    XP_038939348.1
    XP_038939350.1
    XP_063123111.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009362.2 → NP_001009362.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_001009362.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0
      Related
      ENSRNOP00000022748.3, ENSRNOT00000022748.8
      Conserved Domains (3) summary
      cd00130
      Location:129 → 228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:1061 → 1314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343 → 386
      PAS_9; PAS domain

    2. NM_001432217.1 → NP_001419146.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0

    3. NM_001432218.1 → NP_001419147.1  PAS domain-containing serine/threonine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      F7F091, Q5PQT0

    4. NM_001432219.1 → NP_001419148.1  PAS domain-containing serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GFT4

    5. NM_001432220.1 → NP_001419149.1  PAS domain-containing serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GFT4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101291673..101333288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083420.2 → XP_038939348.1  PAS domain-containing serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      F7F091, Q5PQT0
      Conserved Domains (3) summary
      cd00130
      Location:129 → 228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:1061 → 1314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343 → 386
      PAS_9; PAS domain

    2. XM_039083422.2 → XP_038939350.1  PAS domain-containing serine/threonine-protein kinase isoform X2

      Conserved Domains (2) summary
      smart00091
      Location:129 → 177
      PAS; PAS domain
      cd14004
      Location:1014 → 1267
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase

    3. XM_039083419.2 → XP_038939347.1  PAS domain-containing serine/threonine-protein kinase isoform X1

      Conserved Domains (3) summary
      cd00130
      Location:129 → 228
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd14004
      Location:1061 → 1314
      STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase
      pfam13426
      Location:343 → 386
      PAS_9; PAS domain

    4. XM_063267041.1 → XP_063123111.1  PAS domain-containing serine/threonine-protein kinase isoform X2

      Related
      ENSRNOP00000087231.1, ENSRNOT00000095651.2
    Nucleotide Protein Strain
    Heading Accession and Version

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