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    Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wars2provided by RGD
    Official Full Name
    tryptophanyl tRNA synthetase 2 (mitochondrial)provided by RGD
    Primary source
    RGD:1593417
    See related
    EnsemblRapid:ENSRNOG00000019508 AllianceGenome:RGD:1593417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tryptophan-tRNA ligase activity. Involved in positive regulation of angiogenesis. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in mitochondrial matrix. Orthologous to human WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 59.5), Kidney (RPKM 52.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wars2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (189150322..189233606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (186459744..186543581)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (201170363..201256115)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485938 Neighboring gene ribosomal protein L8, pseudogene 2 Neighboring gene T-box transcription factor 15 Neighboring gene uncharacterized LOC102553016 Neighboring gene ribosomal protein S10, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Pravenec M, et al. Physiol Res, 2017 Dec 20. PMID 29261326
    2. T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification. Banin E, et al. Invest Ophthalmol Vis Sci, 2006 May. PMID 16639024
    3. Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability. Musante L, et al. Hum Mutat, 2017 Jun. PMID 28236339
    4. Wars2 is a determinant of angiogenesis. Wang M, et al. Nat Commun, 2016 Jul 8. PMID 27389904, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data demonstrate a pro-angiogenic function for Wars2 both within and outside the heart.
      Title: Wars2 is a determinant of angiogenesis.
    2. Wars2 gene regulates brown adipose tissue function and consequently lipid and glucose metabolism.
      Title: Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase, mitochondrial
    NP_001162112.1
    XP_006233090.1
    XP_038959090.1
    XP_038959091.1
    XP_063138660.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168641.1 → NP_001162112.1  tryptophan--tRNA ligase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1M8H2
      Related
      ENSRNOP00000111540.1, ENSRNOT00000126675.1
      Conserved Domains (2) summary
      cd00806
      Location:36 → 312
      TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
      PRK00927
      Location:35 → 360
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      189150322..189233606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233028.5 → XP_006233090.1  tryptophan--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6ANK9
      Related
      ENSRNOP00000097628.1, ENSRNOT00000104876.2
      Conserved Domains (2) summary
      cd00806
      Location:36 → 285
      TrpRS_core; catalytic core domain of tryptophanyl-tRNA synthetase
      PRK00927
      Location:35 → 333
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    2. XM_063282590.1 → XP_063138660.1  tryptophan--tRNA ligase, mitochondrial isoform X4

    3. XM_039103163.2 → XP_038959091.1  tryptophan--tRNA ligase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PRK00927
      Location:35 → 180
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed

    4. XM_039103162.2 → XP_038959090.1  tryptophan--tRNA ligase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6K3E6
      Conserved Domains (1) summary
      PRK00927
      Location:30 → 274
      PRK00927; tryptophanyl-tRNA synthetase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version

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