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    Fkbpl FKBP prolyl isomerase like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fkbplprovided by RGD
    Official Full Name
    FKBP prolyl isomerase likeprovided by RGD
    Primary source
    RGD:1303227
    See related
    EnsemblRapid:ENSRNOG00000000432 AllianceGenome:RGD:1303227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within regulation of blood vessel branching. Predicted to be located in extracellular region. Orthologous to human FKBPL (FKBP prolyl isomerase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 198.9), Muscle (RPKM 72.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fkbpl in Genome Data Viewer
    Location:
    20p12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4104457..4105927, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4099845..4101315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4411890..4413360)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483856 Neighboring gene uncharacterized LOC120098978 Neighboring gene activating transcription factor 6 beta Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. Yakkundi A, et al. Arterioscler Thromb Vasc Biol, 2015 Apr. PMID 25767277, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of blood vessel branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FK506-binding protein-like
    Names
    FK506 binding protein-like
    WAF-1/CIP1 stabilizing protein 39
    WISp39
    NP_001002818.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002818.2 → NP_001002818.1  FK506-binding protein-like

      See identical proteins and their annotated locations for NP_001002818.1

      Status: VALIDATED

      Source sequence(s)
      BC086532
      UniProtKB/Swiss-Prot
      Q6MG81
      UniProtKB/TrEMBL
      A6KTJ1
      Related
      ENSRNOP00000000494.3, ENSRNOT00000000494.8
      Conserved Domains (3) summary
      sd00006
      Location:208 → 236
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:285 → 317
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:252 → 315
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4104457..4105927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG81.1 GenPept UniProtKB/Swiss-Prot:Q6MG81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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