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    Pls1 plastin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pls1provided by RGD
    Official Full Name
    plastin 1provided by RGD
    Primary source
    RGD:1307142
    See related
    EnsemblRapid:ENSRNOG00000009945 AllianceGenome:RGD:1307142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including actin filament organization; inner ear receptor cell stereocilium organization; and intestinal D-glucose absorption. Predicted to act upstream of or within terminal web assembly. Predicted to be located in several cellular components, including brush border; stereocilium; and terminal web. Predicted to be active in actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76. Orthologous to human PLS1 (plastin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 189.2), Liver (RPKM 95.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pls1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105196312..105306252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96316703..96426592, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103557361..103659625, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase, pseudogene 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene uncharacterized LOC120094233 Neighboring gene uncharacterized LOC120094232 Neighboring gene ATR serine/threonine kinase Neighboring gene BCL2 interacting protein 3, pseudogene 2 Neighboring gene uncharacterized LOC120094234 Neighboring gene 5'-3' exoribonuclease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Grimm-Günter EM, et al. Mol Biol Cell, 2009 May. PMID 19321664, Free PMC Article
    2. Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Chafel MM, et al. Dev Dyn, 1995 Jun. PMID 7655078
    3. Review series: The cell biology of hearing. Schwander M, et al. J Cell Biol, 2010 Jul 12. PMID 20624897, Free PMC Article
    4. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189074

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intestinal D-glucose absorption ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microvillus length ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within terminal web assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in terminal web assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vestibular receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in terminal web ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plastin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108178.3 → NP_001101648.3  plastin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2QC04

    2. NM_001433806.1 → NP_001420735.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2QC04

    3. NM_001433807.1 → NP_001420736.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2QC04

    4. NM_001433808.1 → NP_001420737.1  plastin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2QC04

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      105196312..105306252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081542.2 → XP_038937470.1  plastin-1 isoform X1

      Conserved Domains (2) summary
      COG5069
      Location:13 → 622
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cl00030
      Location:100 → 244
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_006243574.4 → XP_006243636.1  plastin-1 isoform X1

      Related
      ENSRNOP00000106829.1, ENSRNOT00000147926.1
      Conserved Domains (2) summary
      COG5069
      Location:13 → 622
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cl00030
      Location:100 → 244
      CH_SF; calponin homology (CH) domain superfamily

    3. XM_063265574.1 → XP_063121644.1  plastin-1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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