Copg2 COPI coat complex subunit gamma 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Copg2provided by RGD
Official Full Name: COPI coat complex subunit gamma 2provided by RGD
Primary source: RGD:1566215
See related: EnsemblRapid:ENSRNOG00000011014 AllianceGenome:RGD:1566215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566215
Summary: Predicted to enable structural molecule activity. Predicted to be involved in Golgi vesicle transport; organelle transport along microtubule; and protein secretion. Predicted to be located in COPI-coated vesicle and growth cone. Predicted to be part of COPI vesicle coat. Predicted to be active in Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 344.3), Adrenal (RPKM 226.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (60333455..60468953, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (59366086..59501591, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (58064394..58195242, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE097790 (e-PCR)
- UniSTS:244745

RH141530 (e-PCR)
- UniSTS:223524

Copg2as1 (e-PCR), detects polymorphism
- UniSTS:164902

BE111944 (e-PCR)
- UniSTS:245819

RH139683 (e-PCR)
- UniSTS:221767

RH124785 (e-PCR)
- UniSTS:161607

RH130551 (e-PCR)
- UniSTS:213835

RH141653 (e-PCR)
- UniSTS:223646

RH137477 (e-PCR)
- UniSTS:219565

BF402517 (e-PCR)
- UniSTS:245937

BE110063 (e-PCR)
- UniSTS:245172

RH139028 (e-PCR)
- UniSTS:221114

AU048642 (e-PCR)
- UniSTS:145092

RH127576 (e-PCR)
- UniSTS:210886

AW049845 (e-PCR)
- UniSTS:164317

Copg2 (e-PCR), detects polymorphism
- UniSTS:499175

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intra-Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in intra-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in organelle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of COPI vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPI vesicle coat	IEA Inferred from Electronic Annotation more info
part_of COPI vesicle coat	ISO Inferred from Sequence Orthology more info
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: coatomer subunit gamma-2

Names: coatomer protein complex, subunit gamma 2; gamma-2-COP; gamma-2-coat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106929.2 → NP_001100399.1 coatomer subunit gamma-2

See identical proteins and their annotated locations for NP_001100399.1

Status: VALIDATED

Source sequence(s)

FM088301, FM088672, FM091200, FM099334, FM100327, FM104860, FM120771, FN804600, FN805880, JAXUCZ010000004

UniProtKB/TrEMBL

A0A0H2UHV9, A0A8I5ZST5, A6IEH9

Related

ENSRNOP00000038134.6, ENSRNOT00000033706.7

Conserved Domains (5) summary

COG5240
Location:7 → 866

SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]

pfam08752
Location:613 → 756

COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain

pfam11701
Location:325 → 497

UNC45-central; Myosin-binding striated muscle assembly central

pfam16381
Location:758 → 870

Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform

sd00044
Location:398 → 423

HEAT; HEAT repeat [structural motif]