Entrep1 endosomal transmembrane epsin interactor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Entrep1provided by RGD
Official Full Name: endosomal transmembrane epsin interactor 1provided by RGD
Primary source: RGD:1307524
See related: EnsemblRapid:ENSRNOG00000061147 AllianceGenome:RGD:1307524
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam189a2; RGD1307524
Summary: Predicted to enable ubiquitin ligase activator activity. Predicted to be involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Predicted to be located in endosome membrane and plasma membrane. Orthologous to human ENTREP1 (endosomal transmembrane epsin interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 208.4), Heart (RPKM 89.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (231018987..231073474, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (221592500..221646603, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (241822152..241876089, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin ligase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CXCL12-activated CXCR4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative adaptation of signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endosomal transmembrane epsin interactor 1

Names: family with sequence similarity 189, member A2; protein FAM189A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400818.1 → NP_001387747.1 endosomal transmembrane epsin interactor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K3C3, B2GV30

Related

ENSRNOP00000072580.2, ENSRNOT00000091282.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

231018987..231073474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101391.2 → XP_038957319.1 endosomal transmembrane epsin interactor 1 isoform X1

Conserved Domains (1) summary

pfam04103
Location:99 → 251

CD20; CD20-like family