Cdh11 cadherin 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh11provided by RGD
Official Full Name: cadherin 11provided by RGD
Primary source: RGD:619742
See related: EnsemblRapid:ENSRNOG00000013481 AllianceGenome:RGD:619742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including aortic valve formation; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; and cell junction assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; fibroblast migration; and luteinization. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in Schaffer collateral - CA1 synapse; adherens junction; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome and Teebi hypertelorism syndrome 2. Orthologous to human CDH11 (cadherin 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 132.1), Lung (RPKM 105.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (2152961..2312140)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (2148447..2305754)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (2391181..2551245)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that estradiol mainly promoted cadherin-11 expression in M1-like macrophages of inflamed temporomandibular joint.
Title: Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats.
Higher Cadherin-11 expression was observed only in the high choleserol diet-treated rats with bladder outlet obstruction.
Title: Adhesion molecules of detrusor muscle cells are influenced by a hypercholesterolemic diet or bladder outlet obstruction in a Wistar rat model.
The findings suggest that cadherin-11 may play an important role in synovial fibroblasts from the temporomandibular joint following exposure to mechanical loading and inflammatory stimulation.
Title: Pressure and inflammatory stimulation induced increase of cadherin-11 is mediated by PI3K/Akt pathway in synovial fibroblasts from temporomandibular joint.
Cadherin-11 expression is relatively low in early hippocampus, but high in mature synapses, at postnatal and adult stages. Cadherin-11 might be more important for stabilization of synapses in the postnatal period and adulthood.
Title: Different regulation of N-cadherin and cadherin-11 in rat hippocampus.

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General gene information

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Markers

AU027331 (e-PCR)
- UniSTS:113412

d19rat34 (e-PCR)
- UniSTS:121384

Cdh11 (e-PCR), detects polymorphism
- UniSTS:525889

BE115484 (e-PCR)
- UniSTS:248161

Cdh11 (e-PCR), detects polymorphism
- UniSTS:545908

MARC_14759-14760:1010690749:1 (e-PCR)
- UniSTS:267725

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in aortic valve formation	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within corticospinal tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within estrogen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053392.1 → NP_445844.1 cadherin-11 precursor

See identical proteins and their annotated locations for NP_445844.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6JXY0, F1MAH6

Related

ENSRNOP00000018535.3, ENSRNOT00000018535.7

Conserved Domains (3) summary

cd11304
Location:163 → 264

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:79 → 157

CA; Cadherin repeats

pfam01049
Location:649 → 787

Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

2152961..2312140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278319.1 → XP_063134389.1 cadherin-11 isoform X1

UniProtKB/TrEMBL

A6JXY0, F1MAH6
XM_006255059.5 → XP_006255121.1 cadherin-11 isoform X1

See identical proteins and their annotated locations for XP_006255121.1

UniProtKB/TrEMBL

A6JXY0, F1MAH6

Conserved Domains (3) summary

cd11304
Location:163 → 264

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:79 → 157

CA; Cadherin repeats

pfam01049
Location:649 → 787

Cadherin_C; Cadherin cytoplasmic region