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    Ubqln4 ubiquilin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubqln4provided by RGD
    Official Full Name
    ubiquilin 4provided by RGD
    Primary source
    RGD:1308273
    See related
    EnsemblRapid:ENSRNOG00000019933 AllianceGenome:RGD:1308273
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308273
    Summary
    Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of autophagosome maturation; negative regulation of double-strand break repair via homologous recombination; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including autophagosome; endoplasmic reticulum membrane; and site of DNA damage. Predicted to be part of cytosolic proteasome complex and nuclear proteasome complex. Predicted to be active in cytosol. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 168.4), Thymus (RPKM 165.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubqln4 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176310524..176325724)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174012726..174028062)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187915701..187931035)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member A Neighboring gene RAB25, member RAS oncogene family Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized LOC134485638 Neighboring gene signal sequence receptor subunit 2 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up. Riley BE, et al. J Biol Chem, 2004 Oct 1. PMID 15280365
    2. UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation. Suzuki R, et al. EMBO Rep, 2016 Jun. PMID 27113755, Free PMC Article
    3. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein. Davidson JD, et al. Hum Mol Genet, 2000 Sep 22. PMID 11001934
    4. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, et al. Cell, 2019 Jan 24. PMID 30612738
    5. Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. Matsuda M, et al. Biochem Biophys Res Commun, 2001 Jan 19. PMID 11162551

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43
      Title: A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquilin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107688.1 → NP_001101158.1  ubiquilin-4

      See identical proteins and their annotated locations for NP_001101158.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J690, D4A3P1
      Related
      ENSRNOP00000026994.4, ENSRNOT00000026994.9
      Conserved Domains (4) summary
      smart00727
      Location:186 → 223
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:13 → 83
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:13 → 83
      UBQ; Ubiquitin homologues
      cd14399
      Location:552 → 591
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176310524..176325724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281838.1 → XP_063137908.1  ubiquilin-4 isoform X2

    2. XM_006232642.4 → XP_006232704.1  ubiquilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1E6
      Related
      ENSRNOP00000086536.1, ENSRNOT00000092752.3
      Conserved Domains (4) summary
      smart00727
      Location:186 → 223
      STI1; Heat shock chaperonin-binding motif
      cd01808
      Location:13 → 83
      hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
      smart00213
      Location:13 → 83
      UBQ; Ubiquitin homologues
      cd14399
      Location:499 → 538
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

    3. XM_039102310.2 → XP_038958238.1  ubiquilin-4 isoform X3

      Conserved Domains (2) summary
      cd14399
      Location:310 → 349
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cl17974
      Location:129 → 165
      STI1; STI1 domain

    4. XM_039102311.2 → XP_038958239.1  ubiquilin-4 isoform X4

      Conserved Domains (2) summary
      cd14399
      Location:263 → 302
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      cl17974
      Location:82 → 118
      STI1; STI1 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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