Mast2 microtubule associated serine/threonine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mast2provided by RGD
Official Full Name: microtubule associated serine/threonine kinase 2provided by RGD
Primary source: RGD:1304573
See related: EnsemblRapid:ENSRNOG00000058476 AllianceGenome:RGD:1304573
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and microtubule binding activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of interleukin-12 production; and spermatid differentiation. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 117.8), Muscle (RPKM 101.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135013006..135152195, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129776293..129915502, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135149336..135285337, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAST2 expression patterns are evident in the hippocampus, cerebellum, 3rd ventricle and cerebral cortex of rats.
Title: Expression of the MAST family of serine/threonine kinases.

Submit: New GeneRIF Correction

General gene information

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Markers

BF396654 (e-PCR)
- UniSTS:245831

RH141365 (e-PCR)
- UniSTS:223361

AU048167 (e-PCR)
- UniSTS:109805

RH65021 (e-PCR)
- UniSTS:33279

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in spermatid differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microtubule-associated serine/threonine-protein kinase 2

NP_001101475.2

EC 2.7.11.1

XP_006238736.2

EC 2.7.11.1

XP_006238737.2

EC 2.7.11.1

XP_017448928.2

EC 2.7.11.1

XP_017448930.1

EC 2.7.11.1

XP_038966059.1

EC 2.7.11.1

XP_038966060.1

EC 2.7.11.1

XP_038966061.1

EC 2.7.11.1

XP_038966062.1

EC 2.7.11.1

XP_063143915.1

EC 2.7.11.1

XP_063143916.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108005.3 → NP_001101475.2 microtubule-associated serine/threonine-protein kinase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZMP0, A6JZ72

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

135013006..135152195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238675.5 → XP_006238737.2 microtubule-associated serine/threonine-protein kinase 2 isoform X3

UniProtKB/TrEMBL

A6JZ72

Related

ENSRNOP00000079306.2, ENSRNOT00000114619.2

Conserved Domains (3) summary

cd00992
Location:1102 → 1183

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:512 → 791

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 476

DUF1908; Domain of unknown function (DUF1908)
XM_006238674.5 → XP_006238736.2 microtubule-associated serine/threonine-protein kinase 2 isoform X2

UniProtKB/TrEMBL

A6JZ72

Related

ENSRNOP00000097145.2, ENSRNOT00000102929.2

Conserved Domains (3) summary

cd00992
Location:1109 → 1190

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:519 → 798

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 483

DUF1908; Domain of unknown function (DUF1908)
XM_017593439.3 → XP_017448928.2 microtubule-associated serine/threonine-protein kinase 2 isoform X1

UniProtKB/TrEMBL

A0A8I6ATY6, A6JZ72

Conserved Domains (3) summary

cd00992
Location:1109 → 1190

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:519 → 798

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:202 → 483

DUF1908; Domain of unknown function (DUF1908)
XM_063287846.1 → XP_063143916.1 microtubule-associated serine/threonine-protein kinase 2 isoform X7

UniProtKB/TrEMBL

D3ZAR2
XM_017593441.3 → XP_017448930.1 microtubule-associated serine/threonine-protein kinase 2 isoform X6

UniProtKB/TrEMBL

D3ZAR2
XM_063287845.1 → XP_063143915.1 microtubule-associated serine/threonine-protein kinase 2 isoform X5

UniProtKB/TrEMBL

D3ZAR2
XM_039110131.2 → XP_038966059.1 microtubule-associated serine/threonine-protein kinase 2 isoform X4

UniProtKB/TrEMBL

A0A8I5ZUU6, D3ZAR2

Related

ENSRNOP00000081749.2, ENSRNOT00000096569.2

Conserved Domains (3) summary

cd00992
Location:1023 → 1104

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:433 → 712

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:116 → 397

DUF1908; Domain of unknown function (DUF1908)
XM_039110132.2 → XP_038966060.1 microtubule-associated serine/threonine-protein kinase 2 isoform X8

UniProtKB/TrEMBL

D3ZAR2

Related

ENSRNOP00000086302.2, ENSRNOT00000104664.2

Conserved Domains (3) summary

cd00992
Location:958 → 1039

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:368 → 647

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:51 → 332

DUF1908; Domain of unknown function (DUF1908)
XM_039110133.2 → XP_038966061.1 microtubule-associated serine/threonine-protein kinase 2 isoform X9

UniProtKB/TrEMBL

D3ZAR2

Conserved Domains (3) summary

cd00992
Location:932 → 1013

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:342 → 621

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:25 → 306

DUF1908; Domain of unknown function (DUF1908)
XM_039110134.2 → XP_038966062.1 microtubule-associated serine/threonine-protein kinase 2 isoform X10

UniProtKB/TrEMBL

D3ZAR2

Conserved Domains (3) summary

cd00992
Location:925 → 1006

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd05609
Location:335 → 614

STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase

pfam08926
Location:25 → 299

DUF1908; Domain of unknown function (DUF1908)