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    Akap10 A-kinase anchoring protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akap10provided by RGD
    Official Full Name
    A-kinase anchoring protein 10provided by RGD
    Primary source
    RGD:1308869
    See related
    EnsemblRapid:ENSRNOG00000002899 AllianceGenome:RGD:1308869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    D-akap2
    Summary
    Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrion and plasma membrane. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 78.2), Spleen (RPKM 74.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap10 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47044819..47108153, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46545371..46608730, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48150902..48210074, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480803 Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 Neighboring gene uncharacterized LOC134480804

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Kinderman FS, et al. Mol Cell, 2006 Nov 3. PMID 17081990, Free PMC Article
    2. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Wang L, et al. Proc Natl Acad Sci U S A, 2001 Mar 13. PMID 11248059, Free PMC Article
    3. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, et al. IUBMB Life, 2009 Apr. PMID 19319965, Free PMC Article
    4. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. Burgers PP, et al. Biochemistry, 2015 Jan 13. PMID 25097019
    5. Localized effects of cAMP mediated by distinct routes of protein kinase A. Taskén K, et al. Physiol Rev, 2004 Jan. PMID 14715913

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 10, mitochondrial
    Names
    A kinase (PRKA) anchor protein 10
    Dual specific A kinase anchoring protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114606.2 → NP_001108078.1  A-kinase anchor protein 10, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      CK475954, JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LNB3
      Related
      ENSRNOP00000084439.2, ENSRNOT00000108493.2
      Conserved Domains (3) summary
      cd08721
      Location:383 → 503
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:122 → 367
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:618 → 662
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      47044819..47108153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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