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    Neto1 neuropilin and tolloid like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307206, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neto1provided by RGD
    Official Full Name
    neuropilin and tolloid like 1provided by RGD
    Primary source
    RGD:1566269
    See related
    EnsemblRapid:ENSRNOG00000014006 AllianceGenome:RGD:1566269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566269
    Summary
    Predicted to enable ionotropic glutamate receptor binding activity. Predicted to be involved in learning or memory; modulation of chemical synaptic transmission; and protein localization to synapse. Predicted to act upstream of or within receptor localization to synapse. Predicted to be located in excitatory synapse. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human NETO1 (neuropilin and tolloid like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 85.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Neto1 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (81905455..82028730)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (79635633..79753913)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (83471342..83585043)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene F-box protein 15 Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene ATP binding cassette subfamily G member 2, pseudogene 1 Neighboring gene enolase 1, pseudogene 27 Neighboring gene uncharacterized LOC120098158 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuropilin and tolloid-like protein 1
    Names
    neuropilin (NRP) and tolloid (TLL)-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107371.1NP_001100841.1  neuropilin and tolloid-like protein 1 precursor

      See identical proteins and their annotated locations for NP_001100841.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474021
      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Related
      ENSRNOP00000019384.4, ENSRNOT00000019384.6
      Conserved Domains (2) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      81905455..82028730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255035.5XP_006255097.1  neuropilin and tolloid-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006255097.1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Conserved Domains (2) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    2. XM_039096765.2XP_038952693.1  neuropilin and tolloid-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
      Conserved Domains (2) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:291326
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    3. XM_039096766.2XP_038952694.1  neuropilin and tolloid-like protein 1 isoform X2

      Conserved Domains (2) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:158193
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    4. XM_063277287.1XP_063133357.1  neuropilin and tolloid-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K5M8, D4AAD6
    5. XM_063277288.1XP_063133358.1  neuropilin and tolloid-like protein 1 isoform X5

    6. XM_039096769.2XP_038952697.1  neuropilin and tolloid-like protein 1 isoform X7

      Conserved Domains (1) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    7. XM_008772133.4XP_008770355.1  neuropilin and tolloid-like protein 1 isoform X6

      Conserved Domains (1) summary
      cd00041
      Location:51154
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    8. XM_039096768.2XP_038952696.1  neuropilin and tolloid-like protein 1 isoform X4

      Conserved Domains (2) summary
      cl00049
      Location:1690
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:95130
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    9. XM_039096767.1XP_038952695.1  neuropilin and tolloid-like protein 1 isoform X3

      Conserved Domains (2) summary
      cd00041
      Location:25111
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00104
      Location:116151
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RNA

    1. XR_005496025.2 RNA Sequence