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    Nckap5l NCK-associated protein 5-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nckap5lprovided by RGD
    Official Full Name
    NCK-associated protein 5-likeprovided by RGD
    Primary source
    RGD:1561571
    See related
    EnsemblRapid:ENSRNOG00000056678 AllianceGenome:RGD:1561571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561571
    Summary
    Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be located in centrosome. Predicted to be active in microtubule plus-end. Orthologous to human NCKAP5L (NCK associated protein 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 23.3), Lung (RPKM 21.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nckap5l in Genome Data Viewer
    Location:
    7q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (132433569..132470638, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130553683..130591886, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141081943..141093924, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene formin-like 3 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene uncharacterized LOC134479570 Neighboring gene uncharacterized LOC102546778 Neighboring gene BCDIN3 domain containing RNA methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. Mori Y, et al. PLoS One, 2015. PMID 26485573, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nck-associated protein 5-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271369.4 → NP_001258298.1  nck-associated protein 5-like

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K5W1
      Conserved Domains (4) summary
      PHA03247
      Location:435 → 914
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:203 → 531
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:873 → 1173
      NCKAP5; Nck-associated protein 5, Peripheral clock protein
      cl40461
      Location:58 → 134
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      132433569..132470638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079326.2 → XP_038935254.1  nck-associated protein 5-like isoform X1

      Related
      ENSRNOP00000073580.3, ENSRNOT00000081434.3
      Conserved Domains (4) summary
      PHA03247
      Location:515 → 994
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:283 → 611
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:953 → 1253
      NCKAP5; Nck-associated protein 5, Peripheral clock protein
      cl40461
      Location:138 → 214
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    2. XM_039079328.2 → XP_038935256.1  nck-associated protein 5-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2K5W1
      Conserved Domains (4) summary
      PHA03247
      Location:435 → 914
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:203 → 531
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam15246
      Location:873 → 1173
      NCKAP5; Nck-associated protein 5, Peripheral clock protein
      cl40461
      Location:58 → 134
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    3. XM_063263672.1 → XP_063119742.1  nck-associated protein 5-like isoform X2

      UniProtKB/TrEMBL
      A0A0G2K5W1
      Related
      ENSRNOP00000101031.1, ENSRNOT00000162472.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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