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    Zfp655 zinc finger protein 655 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360764, updated on 9-Dec-2024

    Summary

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    Symbol
    Zfp655provided by RGD
    Full Name
    zinc finger protein 655provided by RGD
    Primary source
    RGD:1309158
    See related
    EnsemblRapid:ENSRNOG00000060129 AllianceGenome:RGD:1309158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf655; RGD1309158
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of G1/S transition of mitotic cell cycle and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in nucleus. Orthologous to human ZNF655 (zinc finger protein 655). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 198.5), Kidney (RPKM 177.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp655 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14466006..14489049, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9349985..9375449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11122779..11146182, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene developmental pluripotency associated 4 like 1 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 394

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. Houlard M, et al. Oncogene, 2005 Jan 6. PMID 15558030
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95009

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 655
    Names
    vav-1 interacting Kruppel-like protein
    zinc finger protein 205-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008362.1 → NP_001008363.1  zinc finger protein 655

      See identical proteins and their annotated locations for NP_001008363.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085937
      UniProtKB/TrEMBL
      A0A0G2K1X7, Q5RKG8
      Related
      ENSRNOP00000072025.1, ENSRNOT00000084637.3
      Conserved Domains (4) summary
      COG5048
      Location:237 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:245 → 265
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:243 → 265
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:257 → 278
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      14466006..14489049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271454.1 → XP_063127524.1  zinc finger protein 655 isoform X7

    2. XM_039089554.2 → XP_038945482.1  zinc finger protein 655 isoform X8

      Conserved Domains (1) summary
      pfam01352
      Location:77 → 117
      KRAB; KRAB box

    3. XM_063271455.1 → XP_063127525.1  zinc finger protein 655 isoform X9

    4. XM_006248895.5 → XP_006248957.1  zinc finger protein 655 isoform X3

      See identical proteins and their annotated locations for XP_006248957.1

      UniProtKB/TrEMBL
      A0A0G2K1X7, Q5RKG8
      Conserved Domains (4) summary
      COG5048
      Location:237 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:245 → 265
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:243 → 265
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:257 → 278
      zf-H2C2_2; Zinc-finger double domain

    5. XM_039089550.2 → XP_038945478.1  zinc finger protein 655 isoform X2

      Related
      ENSRNOP00000064091.2, ENSRNOT00000071795.3
      Conserved Domains (2) summary
      COG5048
      Location:303 → 593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:311 → 331
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_063271445.1 → XP_063127515.1  zinc finger protein 655 isoform X1

      Related
      ENSRNOP00000080958.2, ENSRNOT00000116126.2

    7. XM_063271446.1 → XP_063127516.1  zinc finger protein 655 isoform X1

    8. XM_063271450.1 → XP_063127520.1  zinc finger protein 655 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1X7, Q5RKG8

    9. XM_063271449.1 → XP_063127519.1  zinc finger protein 655 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1X7, Q5RKG8

    10. XM_063271448.1 → XP_063127518.1  zinc finger protein 655 isoform X1

    11. XM_063271447.1 → XP_063127517.1  zinc finger protein 655 isoform X1

    12. XM_063271451.1 → XP_063127521.1  zinc finger protein 655 isoform X4

    13. XM_063271452.1 → XP_063127522.1  zinc finger protein 655 isoform X5

      UniProtKB/TrEMBL
      A6K1E1

    14. XM_006248899.5 → XP_006248961.3  zinc finger protein 655 isoform X8

      Conserved Domains (1) summary
      pfam01352
      Location:77 → 117
      KRAB; KRAB box

    15. XM_039089557.2 → XP_038945485.1  zinc finger protein 655 isoform X11

      UniProtKB/TrEMBL
      A6K1E3
      Related
      ENSRNOP00000112588.1, ENSRNOT00000128934.1

    16. XM_063271457.1 → XP_063127527.1  zinc finger protein 655 isoform X11

      UniProtKB/TrEMBL
      A6K1E3

    17. XM_063271453.1 → XP_063127523.1  zinc finger protein 655 isoform X6

    18. XM_063271456.1 → XP_063127526.1  zinc finger protein 655 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AKX0
      Related
      ENSRNOP00000095143.1, ENSRNOT00000105186.2

    19. XM_003751126.6 → XP_003751174.1  zinc finger protein 655 isoform X6

      Conserved Domains (2) summary
      smart00349
      Location:77 → 123
      KRAB; krueppel associated box
      pfam01352
      Location:77 → 116
      KRAB; KRAB box

    20. XM_008768981.4 → XP_008767203.1  zinc finger protein 655 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AKX0

    RNA

    1. XR_001840600.3 RNA Sequence

    2. XR_010056400.1 RNA Sequence

    3. XR_010056401.1 RNA Sequence

    4. XR_005491645.2 RNA Sequence

    5. XR_010056402.1 RNA Sequence

    6. XR_010056403.1 RNA Sequence

      Related
      ENSRNOT00000115559.2
    Nucleotide Protein Strain
    Heading Accession and Version

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