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    Tmem68 transmembrane protein 68 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem68provided by RGD
    Official Full Name
    transmembrane protein 68provided by RGD
    Primary source
    RGD:1309006
    See related
    EnsemblRapid:ENSRNOG00000008872 AllianceGenome:RGD:1309006
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309006
    Summary
    Predicted to enable phospholipid:diacylglycerol acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human TMEM68 (transmembrane protein 68). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 75.6), Kidney (RPKM 63.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem68 in Genome Data Viewer
    Location:
    5q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21291675..21322443, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16494054..16524842, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16363908..16413307, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene XK related 4 Neighboring gene uncharacterized LOC103695237 Neighboring gene uncharacterized LOC120103059 Neighboring gene trimethylguanosine synthase 1 Neighboring gene sterol carrier protein 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid:diacylglycerol acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DGAT1/2-independent enzyme synthesizing storage lipids
    NP_001101373.1
    XP_006237889.1
    XP_006237894.1
    XP_038965684.1
    XP_038965685.1
    XP_038965686.1
    XP_038965687.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107903.1 → NP_001101373.1  DGAT1/2-independent enzyme synthesizing storage lipids

      See identical proteins and their annotated locations for NP_001101373.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Related
      ENSRNOP00000012215.3, ENSRNOT00000012215.6
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      21291675..21322443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237827.5 → XP_006237889.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      See identical proteins and their annotated locations for XP_006237889.1

      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    2. XM_006237832.5 → XP_006237894.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X2

      Conserved Domains (1) summary
      cd07987
      Location:103 → 295
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    3. XM_039109759.2 → XP_038965687.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    4. XM_039109757.2 → XP_038965685.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    5. XM_039109756.2 → XP_038965684.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    6. XM_039109758.2 → XP_038965686.1  DGAT1/2-independent enzyme synthesizing storage lipids isoform X1

      UniProtKB/TrEMBL
      A6JFK5, D3ZF19
      Conserved Domains (1) summary
      cd07987
      Location:103 → 309
      LPLAT_MGAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like

    RNA

    1. XR_005504424.2 RNA Sequence

    2. XR_010066376.1 RNA Sequence

    3. XR_005504426.2 RNA Sequence

    4. XR_005504425.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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