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    Rasa2 RAS p21 protein activator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasa2provided by RGD
    Official Full Name
    RAS p21 protein activator 2provided by RGD
    Primary source
    RGD:3538
    See related
    EnsemblRapid:ENSRNOG00000011909 AllianceGenome:RGD:3538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GAP1M
    Summary
    Enables GTPase activator activity. Predicted to be involved in intracellular signal transduction and negative regulation of Ras protein signal transduction. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 146.3), Kidney (RPKM 143.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasa2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105996797..106116285, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97119983..97236687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104417827..104542313, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094236 Neighboring gene leucine rich repeat containing 78 Neighboring gene uncharacterized LOC120094237 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene zinc finger and BTB domain containing 38 Neighboring gene uncharacterized LOC100909637 Neighboring gene uncharacterized LOC134480088

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Next-generation sequencing identifies rare variants associated with Noonan syndrome. Chen PC, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049390, Free PMC Article
    2. Purification of a novel ras GTPase-activating protein from rat brain. Maekawa M, et al. J Biol Chem, 1993 Oct 25. PMID 8226805
    3. A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions. Maekawa M, et al. Mol Cell Biol, 1994 Oct. PMID 7935405, Free PMC Article
    4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105724.1 → NP_001099194.1  ras GTPase-activating protein 2

      See identical proteins and their annotated locations for NP_001099194.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473954
      UniProtKB/Swiss-Prot
      Q63713
      UniProtKB/TrEMBL
      A6I283
      Related
      ENSRNOP00000016327.4, ENSRNOT00000016327.7
      Conserved Domains (7) summary
      smart00107
      Location:706 → 741
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:171 → 313
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:38 → 158
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      smart00323
      Location:300 → 641
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13370
      Location:589 → 721
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      pfam00169
      Location:606 → 704
      PH; PH domain
      cl02569
      Location:322 → 592
      RasGAP; Ras GTPase Activating Domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      105996797..106116285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080892.2 → XP_038936820.1  ras GTPase-activating protein 2 isoform X1

      Conserved Domains (5) summary
      smart00107
      Location:649 → 684
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114 → 256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd13370
      Location:532 → 664
      PH_GAP1m_mammal-like; GTPase activating protein 1 m pleckstrin homology (PH) domain
      cl02569
      Location:265 → 535
      RasGAP; Ras GTPase Activating Domain
      cl14603
      Location:1 → 101
      C2; C2 domain

    2. XM_063264951.1 → XP_063121021.1  ras GTPase-activating protein 2 isoform X2

    3. XM_063264952.1 → XP_063121022.1  ras GTPase-activating protein 2 isoform X3

    RNA

    1. XR_010053933.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63713.1 GenPept UniProtKB/Swiss-Prot:Q63713

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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