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    Dok1 docking protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dok1provided by RGD
    Official Full Name
    docking protein 1provided by RGD
    Primary source
    RGD:1309499
    See related
    EnsemblRapid:ENSRNOG00000007412 AllianceGenome:RGD:1309499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dok-1
    Summary
    Predicted to be involved in Ras protein signal transduction; cell surface receptor protein tyrosine kinase signaling pathway; and positive regulation of MAPK cascade. Predicted to act upstream of or within intracellular signal transduction and macrophage colony-stimulating factor signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human DOK1 (docking protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 86.2), Adrenal (RPKM 61.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dok1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117095171..117098251, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115537453..115540464, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113864211..113866695, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene meiosis 1 associated protein Neighboring gene small ribosomal subunit protein eS6-like Neighboring gene uncharacterized LOC120102319 Neighboring gene lysyl oxidase-like 3 Neighboring gene HtrA serine peptidase 2 Neighboring gene AUP1, lipid droplet regulating VLDL assembly factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Hiragun T, et al. Mol Pharmacol, 2005 Mar. PMID 15608142
    2. Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor. Abramson J, et al. Eur J Immunol, 2003 Jan. PMID 12594836
    3. Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells. Park S, et al. J Biol Chem, 1993 Dec 5. PMID 7503985
    4. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. Goel RK, et al. FEBS J, 2013 Sep. PMID 23822091
    5. Clustering the mast cell function-associated antigen (MAFA) leads to tyrosine phosphorylation of p62Dok and SHIP and affects RBL-2H3 cell cycle. Abramson J, et al. Immunol Lett, 2002 Jun 3. PMID 12008030

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dok-1 is the mediator of the antiallergic actions of dexamethasone and as a negative regulator of the MAP kinase pathway and downstream release of inflammatory mediators.
      Title: Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within macrophage colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 1
    Names
    downstream of tyrosine kinase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025416.1 → NP_001020587.1  docking protein 1

      See identical proteins and their annotated locations for NP_001020587.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097972
      UniProtKB/Swiss-Prot
      Q4QQV2
      UniProtKB/TrEMBL
      A6IAI5
      Related
      ENSRNOP00000010020.5, ENSRNOT00000010020.6
      Conserved Domains (2) summary
      cd01203
      Location:151 → 253
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:6 → 119
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117095171..117098251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763022.4 → XP_008761244.1  docking protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UI78
      Conserved Domains (3) summary
      cd01203
      Location:144 → 246
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      pfam00169
      Location:14 → 109
      PH; PH domain
      cl17171
      Location:14 → 112
      PH-like; Pleckstrin homology-like domain

    2. XM_039107585.2 → XP_038963513.1  docking protein 1 isoform X2

      Conserved Domains (2) summary
      cd01203
      Location:88 → 190
      PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
      cl17171
      Location:2 → 56
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQV2.1 GenPept UniProtKB/Swiss-Prot:Q4QQV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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