PFN2 profilin 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: PFN2
Official Full Name: profilin 2
Primary source: TAIR:AT4G29350
Locus tag: AT4G29350
See related: Araport:AT4G29350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F17A13.170; F17A13_170; PRF2; PRO2; PROFILIN; profilin 2; PROFILIN 2
Summary: Encodes profilin2, a low-molecular weight, actin monomer-binding protein that regulates the organization of actin cytoskeleton. Expressed in vegetative organs. The first intron of PRF2 enhances gene expression.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Upregulation of profilin 2 by BFA was verified by immunoblot and live imaging at subcellular level.
Title: Proteomics on brefeldin A-treated Arabidopsis roots reveals profilin 2 as a new protein involved in the cross-talk between vesicular trafficking and the actin cytoskeleton.
localized to polygonal meshes resembling the endoplasmic reticulum
Title: Arabidopsis profilin isoforms, PRF1 and PRF2 show distinctive binding activities and subcellular distributions.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_119080.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin polymerization or depolymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inflorescence development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in plasma membrane	HDA more info	PubMed

NP_194664.1

profilin 2 (PFN2); FUNCTIONS IN: actin binding, protein binding; INVOLVED IN: actin polymerization or depolymerization, cytoskeleton organization; LOCATED IN: chloroplast, plasma membrane, actin cytoskeleton, cytoplasm; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Profilin/allergen (InterPro:IPR002097), Profilin, plant (InterPro:IPR005455); BEST Arabidopsis thaliana protein match is: profilin 1 (TAIR:AT2G19760.1); Has 925 Blast hits to 924 proteins in 248 species: Archae - 0; Bacteria - 2; Metazoa - 138; Fungi - 123; Plants - 584; Viruses - 0; Other Eukaryotes - 78 (source: NCBI BLink).