Zpr1 ZPR1 zinc finger [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zpr1provided by RGD
Official Full Name: ZPR1 zinc fingerprovided by RGD
Primary source: RGD:1562173
See related: EnsemblRapid:ENSRNOG00000018481 AllianceGenome:RGD:1562173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp259; RGD1562173
Summary: Predicted to enable receptor tyrosine kinase binding activity; translation initiation factor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including Cajal body organization; blastocyst growth; and nervous system development. Predicted to act upstream of or within with a positive effect on DNA replication. Predicted to be located in growth cone; nuclear lumen; and perikaryon. Predicted to be active in Cajal body; axon; and cytoplasm. Orthologous to human ZPR1 (ZPR1 zinc finger). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 134.5), Testes (RPKM 120.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55461839..55471413)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46564898..46574719)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50563047..50572621)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH139127 (e-PCR)
- UniSTS:221213

BE102182 (e-PCR)
- UniSTS:244082

AU026411 (e-PCR)
- UniSTS:114306

RH139835 (e-PCR)
- UniSTS:221919

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Cajal body organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Cajal body organization	ISO Inferred from Sequence Orthology more info
involved_in DNA endoreduplication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect DNA replication	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in development	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in pre-mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Cajal body	IBA Inferred from Biological aspect of Ancestor more info
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in Gemini of coiled bodies	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein ZPR1

Names: zinc finger protein 259

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001137646.1 → NP_001131118.1 zinc finger protein ZPR1

See identical proteins and their annotated locations for NP_001131118.1

Status: PROVISIONAL

Source sequence(s)

CH473975

UniProtKB/TrEMBL

A0A8I6AUQ7, A6J476, D3ZWN1

Related

ENSRNOP00000025149.4, ENSRNOT00000025149.7

Conserved Domains (2) summary

smart00709
Location:257 → 416

Zpr1; Duplicated domain in the epidermal growth factor- and elongation factor-1alpha-binding protein Zpr1. Also present in archaeal proteins

pfam03367
Location:49 → 206

zf-ZPR1; ZPR1 zinc-finger domain