Man2a1 mannosidase, alpha, class 2A, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Man2a1provided by RGD
Official Full Name: mannosidase, alpha, class 2A, member 1provided by RGD
Primary source: RGD:3038
See related: EnsemblRapid:ENSRNOG00000015439 AllianceGenome:RGD:3038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mana2; Manno
Summary: Enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity and protein homodimerization activity. Involved in N-glycan processing. Located in Golgi membrane. Orthologous to human MAN2A1 (mannosidase alpha class 2A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 324.0), Liver (RPKM 250.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q37

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (111698913..111855257)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (104252001..104408349)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (112293388..112451677)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that hepatocyte expression of Man2a1 (Golgi apparatus alpha-mannosidase) and Man2b1 (lysosome alpha-mannosidase) is down-regulated by biological toxin swainsonine as part of locoweed/Oxytropis kansuensis hepatotoxic damage.
Title: The effects of swainsonine on the activity and expression of α-mannosidase in BRL-3A cells.
swainsonine from Oxytropis kansuensis could reduce the expression of MAN2A1 in brain tissues
Title: Effect of swainsonine in Oxytropis kansuensis on Golgi α-mannosidase II expression in the brain tissues of Sprague-Dawley rats.
Man2a1 expression increases at night ~10-fold in the rat pineal gland, by a mechanism involving neural stimulation and norepinephrine - cyclic AMP control.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU027840 (e-PCR)
- UniSTS:112913

RH143712 (e-PCR)
- UniSTS:232958

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-mannosidase activity	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables mannosidase activity	ISO Inferred from Sequence Orthology more info
enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-glycan processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within N-glycan processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in mannose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vacuole organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi medial cisterna	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-mannosidase 2

Names: AMan II; MAN II; alpha-mannosidase II; golgi alpha-mannosidase II; mannosidase 2, alpha 1; mannosidase alpha 2; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

NP_037111.2

EC 3.2.1.114

XP_038938965.1

EC 3.2.1.114

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012979.2 → NP_037111.2 alpha-mannosidase 2

See identical proteins and their annotated locations for NP_037111.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

G3V7Y9, P28494

Related

ENSRNOP00000020767.5, ENSRNOT00000020767.8

Conserved Domains (4) summary

PLN02701
Location:127 → 1148

PLN02701; alpha-mannosidase

cd11666
Location:164 → 507

GH38N_Man2A1; N-terminal catalytic domain of Golgi alpha-mannosidase II and similar proteins; glycoside hydrolase family 38 (GH38)

smart00872
Location:502 → 587

Alpha-mann_mid; Alpha mannosidase, middle domain

pfam07748
Location:733 → 1142

Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain