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    Dtymk deoxythymidylate kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtymkprovided by RGD
    Official Full Name
    deoxythymidylate kinaseprovided by RGD
    Primary source
    RGD:1309614
    See related
    EnsemblRapid:ENSRNOG00000018904 AllianceGenome:RGD:1309614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; nucleoside diphosphate kinase activity; and thymidylate kinase activity. Involved in several processes, including pyrimidine deoxyribonucleotide biosynthetic process; response to cadmium ion; and response to estrogen. Located in mitochondrial matrix. Orthologous to human DTYMK (deoxythymidylate kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 223.9), Spleen (RPKM 176.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtymk in Genome Data Viewer
    Location:
    9q36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (101762899..101771733, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (94315552..94324386, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (100921565..100930399, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene THAP domain containing 4 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene inhibitor of growth family, member 5 Neighboring gene D-2-hydroxyglutarate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat. Thomson MJ, et al. Cancer Res, 1973 Feb. PMID 4347462
    2. Metabolic alterations of liver regeneration. XV. Cadmium-mediated depression of thymidine and thymidylate kinase induction in rats. Cihák A. Chem Biol Interact, 1979 May. PMID 223769
    3. Relationship between 5'-nucleotidase, adenosine deaminase, AMP deaminase, ATP-(Mg2+)-ase activities and dTMP kinase activity in rat liver mitochondria. Greger J, et al. Enzyme, 1979. PMID 220041
    4. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs. Rylova SN, et al. Biochem Pharmacol, 2005 Mar 15. PMID 15748706
    5. Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. Cummins RR, et al. Cancer Res, 1980 Apr. PMID 6244089

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dTDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dTTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTTP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dUDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myoblast differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in thymidine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thymidylate kinase
    NP_001100395.1
    XP_006245581.1
    XP_008765585.1
    XP_038939353.1
    XP_063123113.1
    XP_063123114.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106925.1 → NP_001100395.1  thymidylate kinase

      See identical proteins and their annotated locations for NP_001100395.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473997
      UniProtKB/TrEMBL
      A6JR35
      Conserved Domains (2) summary
      PLN02924
      Location:5 → 211
      PLN02924; thymidylate kinase
      pfam02223
      Location:11 → 191
      Thymidylate_kin; Thymidylate kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      101762899..101771733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245519.5 → XP_006245581.1  thymidylate kinase isoform X1

      Conserved Domains (2) summary
      PLN02924
      Location:5 → 187
      PLN02924; thymidylate kinase
      pfam02223
      Location:11 → 167
      Thymidylate_kin; Thymidylate kinase

    2. XM_039083425.2 → XP_038939353.1  thymidylate kinase isoform X4

      Conserved Domains (1) summary
      cl17190
      Location:5 → 154
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. XM_008767363.4 → XP_008765585.1  thymidylate kinase isoform X3

      Conserved Domains (1) summary
      PLN02924
      Location:5 → 178
      PLN02924; thymidylate kinase

    4. XM_063267044.1 → XP_063123114.1  thymidylate kinase isoform X5

      UniProtKB/TrEMBL
      A6JR36

    5. XM_063267043.1 → XP_063123113.1  thymidylate kinase isoform X2

    RNA

    1. XR_005488878.2 RNA Sequence

      Related
      ENSRNOT00000085029.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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