HA2 H[+]-ATPase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HA2
Official Full Name: H[+]-ATPase 2
Primary source: TAIR:AT4G30190
Locus tag: AT4G30190
See related: Araport:AT4G30190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHA2; F9N11.40; F9N11_40; H(+)-ATPase 2; P-TYPE H(+)-ATPASE ISOFORM 2; PLASMA MEMBRANE PROTON ATPASE 2; PMA2
Summary: belongs to the P-type ATPase superfamily of cation-transporting ATPases, pumps protons out of the cell, generating a proton gradient that drives the active transport of nutrients by proton symport. has two autoinhibitory regions within the C-terminal dom
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Genomic context

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See HA2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 14

Sequence:: Chromosome: 4; NC_003075.7 (14770395..14776247, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transceptor NRT1.1 and receptor-kinase QSK1 complex controls PM H[+]-ATPase activity under low nitrate.
Title: Transceptor NRT1.1 and receptor-kinase QSK1 complex controls PM H(+)-ATPase activity under low nitrate.
Arabidopsis leaf hydraulic conductance is regulated by xylem sap pH, controlled, in turn, by a P-type H(+) -ATPase of vascular bundle sheath cells.
Title: Arabidopsis leaf hydraulic conductance is regulated by xylem sap pH, controlled, in turn, by a P-type H(+) -ATPase of vascular bundle sheath cells.
A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase.
Title: A conserved, buried cysteine near the P-site is accessible to cysteine modifications and increases ROS stability in the P-type plasma membrane H+-ATPase.
Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.
Title: Danger-Associated Peptide Regulates Root Growth by Promoting Protons Extrusion in an AHA2-Dependent Manner in Arabidopsis.
Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker.
Title: Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker.
Study find that AHA2 drives root cell expansion during growth but that, unexpectedly, restriction of root hair elongation is dependent on AHA2 and AHA7, with each having different roles in this process.
Title: Roles of plasma membrane proton ATPases AHA2 and AHA7 in normal growth of roots and root hairs in Arabidopsis thaliana.
A "head-to-tail" organization of ATPase monomers in which the C-terminal domain of one ATPase molecule interacts with the actuator domain of another ATPase molecule.
Title: In vivo cross-linking supports a head-to-tail mechanism for regulation of the plant plasma membrane P-type H(+)-ATPase.
The accumulation of AHA2 in intracellular compartments is consistent with reduced H(+) secretion near the transition zone and the suppression of root growth.
Title: Environmental and Genetic Factors Regulating Localization of the Plant Plasma Membrane H(+)-ATPase.
Under low-phosphorus stress conditions, AHA2 acts mainly to modulate primary root elongation by mediating H+ efflux in the root elongation zone, whereas AHA7 plays an important role in root hair formation by mediating H+ efflux in the root hair zone.
Title: Arabidopsis plasma membrane H+-ATPase genes AHA2 and AHA7 have distinct and overlapping roles in the modulation of root tip H+ efflux in response to low-phosphorus stress.
the PM proton pump AHA2 (Arabidopsis plasma membrane H(+) -ATPase isoform 2) is important for root growth and development during different nitrogen regimes.
Title: The plasma membrane H(+) -ATPase AHA2 contributes to the root architecture in response to different nitrogen supply.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203941.2

Supported by ESTs:

NM_119165.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables P-type proton-exporting transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type proton-exporting transporter activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in proton export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: H[+]-ATPase 2

NP_001190870.1

H(+)-ATPase 2 (HA2); FUNCTIONS IN: ATPase activity, hydrogen-exporting ATPase activity, phosphorylative mechanism; INVOLVED IN: cation transport, metabolic process, ATP biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, plasma-membrane proton-efflux (InterPro:IPR006534), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: H(+)-ATPase 1 (TAIR:AT2G18960.1).

NP_194748.1

H(+)-ATPase 2 (HA2); FUNCTIONS IN: ATPase activity, hydrogen-exporting ATPase activity, phosphorylative mechanism; INVOLVED IN: cation transport, metabolic process, ATP biosynthetic process; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type cation-transporter, N-terminal (InterPro:IPR004014), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type, plasma-membrane proton-efflux (InterPro:IPR006534), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: H(+)-ATPase 1 (TAIR:AT2G18960.1); Has 36409 Blast hits to 32614 proteins in 3160 species: Archae - 700; Bacteria - 23090; Metazoa - 3798; Fungi - 2556; Plants - 1882; Viruses - 3; Other Eukaryotes - 4380 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

14770395..14776247 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119165.4 → NP_194748.1 H[+]-ATPase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194748.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P19456

UniProtKB/TrEMBL

A0A178UV39, A0A5S9XX77, C0Z2R2

Conserved Domains (1) summary

TIGR01647
Location:32 → 804

ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase
NM_001203941.2 → NP_001190870.1 H[+]-ATPase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190870.1

Status: REVIEWED

UniProtKB/TrEMBL

C0Z2R2, F4JPJ7

Conserved Domains (4) summary

smart00831
Location:12 → 74

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:576 → 664

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01647
Location:32 → 837

ATPase-IIIA_H; plasma-membrane proton-efflux P-type ATPase

pfam00122
Location:97 → 318

E1-E2_ATPase; E1-E2 ATPase