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    Ppp1r12b protein phosphatase 1, regulatory subunit 12B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppp1r12bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 12Bprovided by RGD
    Primary source
    RGD:1309287
    See related
    EnsemblRapid:ENSRNOG00000051440 AllianceGenome:RGD:1309287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in neuron projection morphogenesis. Predicted to be located in stress fiber. Predicted to be active in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 207.7), Muscle (RPKM 206.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r12b in Genome Data Viewer
    Location:
    13q13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48751256..48948933, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46199418..46397108, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51583603..51784641, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene MGAT4 family member E Neighboring gene lysine demethylase 5B Neighboring gene synaptotagmin 2 Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 4 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B. Liu K, et al. EBioMedicine, 2020 Nov. PMID 33096475, Free PMC Article
    2. Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. Arimura T, et al. J Biol Chem, 2001 Mar 2. PMID 11067852
    3. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
      Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 12B
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 12B
    NP_001100648.1
    XP_006249937.1
    XP_006249938.1
    XP_006249942.1
    XP_008767780.1
    XP_008767783.1
    XP_017454282.1
    XP_038946646.1
    XP_038946647.1
    XP_038946648.1
    XP_063128370.1
    XP_063128371.1
    XP_063128373.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107178.5 → NP_001100648.1  protein phosphatase 1 regulatory subunit 12B

      See identical proteins and their annotated locations for NP_001100648.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6A534, A6ICC9, D3ZIC4
      Related
      ENSRNOP00000069748.1, ENSRNOT00000089068.3
      Conserved Domains (5) summary
      cd00204
      Location:85 → 269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:219 → 269
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:876 → 982
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48751256..48948933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272303.1 → XP_063128373.1  protein phosphatase 1 regulatory subunit 12B isoform X12

      UniProtKB/TrEMBL
      A0A8I6A534

    2. XM_006249876.5 → XP_006249938.1  protein phosphatase 1 regulatory subunit 12B isoform X3

      UniProtKB/TrEMBL
      A0A8I6A534, A0A8I6A6B6
      Related
      ENSRNOP00000086607.1, ENSRNOT00000107681.2
      Conserved Domains (5) summary
      cd00204
      Location:85 → 269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:219 → 269
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:876 → 976
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]

    3. XM_008769561.4 → XP_008767783.1  protein phosphatase 1 regulatory subunit 12B isoform X11

      UniProtKB/TrEMBL
      A0A8I6GIK9
      Related
      ENSRNOP00000090864.1, ENSRNOT00000119339.2
      Conserved Domains (1) summary
      pfam15898
      Location:85 → 185
      PRKG1_interact; cGMP-dependent protein kinase interacting domain

    4. XM_006249875.4 → XP_006249937.1  protein phosphatase 1 regulatory subunit 12B isoform X1

      UniProtKB/TrEMBL
      A0A8I6A534
      Related
      ENSRNOP00000087080.1, ENSRNOT00000100540.2
      Conserved Domains (5) summary
      cd00204
      Location:85 → 269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:219 → 269
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:876 → 982
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]

    5. XM_039090719.2 → XP_038946647.1  protein phosphatase 1 regulatory subunit 12B isoform X4

      UniProtKB/TrEMBL
      A0A8I6A534
      Related
      ENSRNOP00000087409.2, ENSRNOT00000100428.2
      Conserved Domains (6) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      PRK07003
      Location:530 → 702
      PRK07003; DNA polymerase III subunit gamma/tau
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:834 → 940
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl40436
      Location:567 → 619
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    6. XM_006249880.5 → XP_006249942.1  protein phosphatase 1 regulatory subunit 12B isoform X8

      See identical proteins and their annotated locations for XP_006249942.1

      UniProtKB/TrEMBL
      A0A8I6A534
      Conserved Domains (4) summary
      cd00204
      Location:47 → 133
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam13637
      Location:51 → 101
      Ank_4; Ankyrin repeats (many copies)
      pfam15898
      Location:708 → 814
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      sd00045
      Location:48 → 79
      ANK; ANK repeat [structural motif]

    7. XM_063272301.1 → XP_063128371.1  protein phosphatase 1 regulatory subunit 12B isoform X10

    8. XM_039090718.2 → XP_038946646.1  protein phosphatase 1 regulatory subunit 12B isoform X2

      UniProtKB/TrEMBL
      A0A8I6A534
      Conserved Domains (6) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      PHA03369
      Location:499 → 786
      PHA03369; capsid maturational protease; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam15898
      Location:876 → 951
      PRKG1_interact; cGMP-dependent protein kinase interacting domain
      cl40436
      Location:609 → 661
      IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

    9. XM_017598793.3 → XP_017454282.1  protein phosphatase 1 regulatory subunit 12B isoform X6

      UniProtKB/TrEMBL
      A0A8I6A534

    10. XM_039090720.2 → XP_038946648.1  protein phosphatase 1 regulatory subunit 12B isoform X7

      UniProtKB/TrEMBL
      A0A8I6A534
      Conserved Domains (5) summary
      PHA03095
      Location:61 → 290
      PHA03095; ankyrin-like protein; Provisional
      PHA03369
      Location:499 → 786
      PHA03369; capsid maturational protease; Provisional
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      cd21944
      Location:606 → 662
      IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)

    11. XM_063272300.1 → XP_063128370.1  protein phosphatase 1 regulatory subunit 12B isoform X5

      UniProtKB/TrEMBL
      A0A8I6A534

    12. XM_008769558.4 → XP_008767780.1  protein phosphatase 1 regulatory subunit 12B isoform X9

      See identical proteins and their annotated locations for XP_008767780.1

      Conserved Domains (4) summary
      cd00204
      Location:85 → 269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:65 → 154
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:219 → 269
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:90 → 121
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_005492243.2 RNA Sequence

    2. XR_010056917.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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