Slu7 SLU7 homolog, splicing factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slu7provided by RGD
Official Full Name: SLU7 homolog, splicing factorprovided by RGD
Primary source: RGD:631432
See related: EnsemblRapid:ENSRNOG00000003822 AllianceGenome:RGD:631432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 92.3), Spleen (RPKM 89.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (28406908..28425253)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (27908325..27923784)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (29029556..29044919)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables pre-mRNA 3'-splice site binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA 3'-splice site binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA 3'-splice site binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables second spliceosomal transesterification activity	ISO Inferred from Sequence Orthology more info
enables second spliceosomal transesterification activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA splicing, via transesterification reactions	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing, via transesterification reactions	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA 3'-splice site recognition	ISO Inferred from Sequence Orthology more info
involved_in mRNA 3'-splice site recognition	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of small nuclear ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of small nuclear ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: pre-mRNA-splicing factor SLU7

Names: SLU7 splicing factor homolog; step II splicing factor SLU7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100550.1 → NP_001094020.1 pre-mRNA-splicing factor SLU7

See identical proteins and their annotated locations for NP_001094020.1

Status: VALIDATED

Source sequence(s)

BC062243, BC158865

UniProtKB/Swiss-Prot

Q6P6G1, Q80ZG5

UniProtKB/TrEMBL

A0A0G2K1S0, B0BNL0

Related

ENSRNOP00000005132.4, ENSRNOT00000005132.7

Conserved Domains (1) summary

pfam11708
Location:161 → 434

Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

28406908..28425253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268963.1 → XP_063125033.1 pre-mRNA-splicing factor SLU7 isoform X1

UniProtKB/Swiss-Prot

Q6P6G1, Q80ZG5

UniProtKB/TrEMBL

A0A0G2K1S0, B0BNL0
XM_008767642.4 → XP_008765864.1 pre-mRNA-splicing factor SLU7 isoform X1

See identical proteins and their annotated locations for XP_008765864.1

UniProtKB/Swiss-Prot

Q6P6G1, Q80ZG5

UniProtKB/TrEMBL

A0A0G2K1S0, B0BNL0

Conserved Domains (1) summary

pfam11708
Location:161 → 434

Slu7; Pre-mRNA splicing Prp18-interacting factor
XM_063268962.1 → XP_063125032.1 pre-mRNA-splicing factor SLU7 isoform X1

UniProtKB/Swiss-Prot

Q6P6G1, Q80ZG5

UniProtKB/TrEMBL

A0A0G2K1S0, B0BNL0