St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St8sia4provided by RGD
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by RGD
Primary source: RGD:621845
See related: EnsemblRapid:ENSRNOG00000019128 AllianceGenome:RGD:621845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Siat8d
Summary: Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in several processes, including N-glycan processing; ganglioside biosynthetic process; and sialylation. Predicted to be located in Golgi apparatus. Orthologous to human ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 209.8), Thymus (RPKM 145.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (103437479..103532008, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (95990131..96084661, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (103117705..103207154, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After learning an olfactory discrimination task, no changes in the expression level of St8sia4 were observed in the olfactory bulb.
Title: Expression of polysialyltransferases (STX and PST) in adult rat olfactory bulb after an olfactory associative discrimination task.
Results suggest that sialyltransferase-X is probably involved in the proliferation of neural progenitor cells; polysialyltransferase may play a key role in synaptic plasticity of mature neural networks
Title: Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.

Submit: New GeneRIF Correction

General gene information

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Markers

BE106499 (e-PCR)
- UniSTS:246289

Siat8d (e-PCR), detects polymorphism
- UniSTS:261923

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sialyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-glycan processing	ISO Inferred from Sequence Orthology more info
involved_in ganglioside biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in sialylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Names: ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4; polysialyltransferase; sialyltransferase 8 (alpha-2, 8-polysialyltransferase) D; sialyltransferase 8 (alpha-2, 8-polysialytransferase) D; sialyltransferase 8 (alpha-2, 8-sialytransferase) D

NP_446366.2

EC 2.4.99.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053914.2 → NP_446366.2 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

O08563

Related

ENSRNOP00000109798.1, ENSRNOT00000163941.1