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    Pnpla8 patatin-like phospholipase domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pnpla8provided by RGD
    Official Full Name
    patatin-like phospholipase domain containing 8provided by RGD
    Primary source
    RGD:1311444
    See related
    EnsemblRapid:ENSRNOG00000039091 AllianceGenome:RGD:1311444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311444
    Summary
    Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in several processes, including arachidonate secretion; glycerophospholipid metabolic process; and unsaturated fatty acid metabolic process. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in membrane. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 458.2), Adrenal (RPKM 448.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pnpla8 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67056783..67118714)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61329810..61391736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64224870..64288465)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103526 Neighboring gene DnaJ heat shock protein family (Hsp40) member B9 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene neuronal cell adhesion molecule Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2. Murakami M, et al. J Biol Chem, 2005 Apr 8. PMID 15695510
    2. A novel intracellular membrane-bound calcium-independent phospholipase A(2). Tanaka H, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833412
    3. The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). Mancuso DJ, et al. J Biol Chem, 2000 Apr 7. PMID 10744668
    4. Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. Mancuso DJ, et al. J Biol Chem, 2007 Mar 23. PMID 17213206
    5. The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling. Yan W, et al. J Biol Chem, 2005 Jul 22. PMID 15908428

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-independent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lysophospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase A1 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in arachidonate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in arachidonate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylcholine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium-independent phospholipase A2-gamma
    Names
    iPLA2-gamma
    intracellular membrane-associated calcium-independent phospholipase A2 gamma
    patatin-like phospholipase domain-containing protein 8
    NP_001101490.2
    XP_063117971.1
    XP_063117972.1
    XP_063117973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108020.2 → NP_001101490.2  calcium-independent phospholipase A2-gamma

      Status: VALIDATED

      Source sequence(s)
      FQ211866, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      D3ZRC4
      UniProtKB/TrEMBL
      A0A1W2Q6C9
      Related
      ENSRNOP00000049214.3, ENSRNOT00000047296.8
      Conserved Domains (1) summary
      cd07211
      Location:429 → 735
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      67056783..67118714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261902.1 → XP_063117972.1  calcium-independent phospholipase A2-gamma isoform X2

    2. XM_063261903.1 → XP_063117973.1  calcium-independent phospholipase A2-gamma isoform X2

    3. XM_063261901.1 → XP_063117971.1  calcium-independent phospholipase A2-gamma isoform X1

      UniProtKB/Swiss-Prot
      D3ZRC4
      UniProtKB/TrEMBL
      A0A1W2Q6C9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZRC4.1 GenPept UniProtKB/Swiss-Prot:D3ZRC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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