RAC3 RAC-like 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAC3
Official Full Name: RAC-like 3
Primary source: TAIR:AT4G35020
Locus tag: AT4G35020
See related: Araport:AT4G35020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARAC3; ATROP6; M4E13.80; M4E13_80; RAC-like 3; RHO-RELATED PROTEIN FROM PLANTS 6; RHO1PS; ROP6
Summary: A member of ROP GTPase gene family; Encodes a Rho-like GTP binding protein.
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Genomic context

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See RAC3 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (16672192..16674789)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDA6 modulates Arabidopsis pavement cell morphogenesis through epigenetic suppression of ROP6 GTPase expression and signaling.
Title: HDA6 modulates Arabidopsis pavement cell morphogenesis through epigenetic suppression of ROP6 GTPase expression and signaling.
GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana.
Title: GTPase ROP6 negatively modulates phosphate deficiency through inhibition of PHT1;1 and PHT1;4 in Arabidopsis thaliana.
A Plasma Membrane Nanodomain Ensures Signal Specificity during Osmotic Signaling in Plants.
Title: A Plasma Membrane Nanodomain Ensures Signal Specificity during Osmotic Signaling in Plants.
Data suggest that Rho-like GTPase 6 (AtROP6) is involved in respiratory burst oxidase homolog D (AtRBOHD)-mediated reactive oxygen species (ROS) signaling to modulate Fe-deficiency responses.
Title: AtROP6 is involved in reactive oxygen species signaling in response to iron-deficiency stress in Arabidopsis thaliana.
Results suggest that during the late petal development stages, SPIKE1 (SPK1), encoding a guanine nucleotide exchange factor and Rho of Plants (ROP) GTPase proteins (ROP2, ROP4, and ROP6)-dependent signaling module influences anisotropic growth in the petal and defines the final organ shape.
Title: SPIKE1 Activates ROP GTPase to Modulate Petal Growth and Shape.
the equilibrium dissociation constants of AtROP66-178 with fluorescent guanine nucleotide analogue mantGDP and mantGTP were determined to be 0.0721 muM and 0.0422 muM, respectively, based on fluorescence polarization.
Title: Expression, purification and characterization of ROP6(6-178) GTPase from Arabidopsis thaliana.
ROP1 and ROP6 are required for F-actin bundle formation in the roots, which is required for P. indica-mediated growth promotion in Arabidopsis.
Title: Arabidopsis ROP1 and ROP6 influence germination time, root morphology, the formation of F-actin bundles, and symbiotic fungal interactions.
Rho of Plants6 (AtROP6) integrates developmental and pathogen response signaling.
Title: The Arabidopsis Rho of plants GTPase AtROP6 functions in developmental and pathogen response pathways.
The ROP6-RIC1 pathway links cytoplasmic auxin signaling to the regulation of cortical microtubule organization and cell elongation
Title: Rho GTPase signaling activates microtubule severing to promote microtubule ordering in Arabidopsis.
ROP6 and its downstream effector RIC1 regulate clathrin association with plasma membrane for clathrin-mediated endocytosis, as well as for its feedback regulation by auxin. Genetic analyses show ROP6/RIC1 acts downstream of ABP1 to regulate endocytosis.
Title: ABP1 and ROP6 GTPase signaling regulate clathrin-mediated endocytosis in Arabidopsis roots.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203987.1

Supported by ESTs:

NM_001203988.2

Supported by ESTs:

NM_001342314.1

Supported by ESTs:

NM_119668.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within_negative_effect anisotropic cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within petal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of auxin mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root hair initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in site of polarized growth	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	HDA more info	PubMed

General protein information

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Preferred Names: RAC-like 3

NP_001190916.1

RAC-like 3 (RAC3); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Ras small GTPase, Rab type (InterPro:IPR003579), Ras (InterPro:IPR013753), Ras small GTPase, Ras type (InterPro:IPR003577), Small GTPase, Rho type (InterPro:IPR003578); BEST Arabidopsis thaliana protein match is: RAC-like GTP binding protein 5 (TAIR:AT1G75840.1).

NP_001190917.1

RAC-like 3 (RAC3); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Ras small GTPase, Rab type (InterPro:IPR003579), Ras (InterPro:IPR013753), Ras small GTPase, Ras type (InterPro:IPR003577), Small GTPase, Rho type (InterPro:IPR003578); BEST Arabidopsis thaliana protein match is: RAC-like GTP binding protein 5 (TAIR:AT1G75840.1).

NP_195228.1

RAC-like 3 (RAC3); FUNCTIONS IN: GTP binding, GTPase activity; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: in 6 components; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Small GTP-binding protein (InterPro:IPR005225), Ras GTPase (InterPro:IPR001806), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579), Ras small GTPase, Ras type (InterPro:IPR003577), Small GTPase, Rho type (InterPro:IPR003578); BEST Arabidopsis thaliana protein match is: RAC-like GTP binding protein 5 (TAIR:AT1G75840.1); Has 24715 Blast hits to 24687 proteins in 684 species: Archae - 9; Bacteria - 73; Metazoa - 12739; Fungi - 3851; Plants - 2699; Viruses - 20; Other Eukaryotes - 5324 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16672192..16674789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001342313.1 → NP_001327974.1 RAC-like 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B372

Conserved Domains (1) summary

cl38936
Location:6 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001203988.2 → NP_001190917.1 RAC-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190917.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92989, Q38912, Q84W42

UniProtKB/TrEMBL

A0A178V1N6, A0A384KTR9, Q5PNX9

Conserved Domains (1) summary

cd04133
Location:6 → 178

Rop_like; Rho-related protein from plants (Rop)-like
NM_001203987.1 → NP_001190916.1 RAC-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190916.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92989, Q38912, Q84W42

UniProtKB/TrEMBL

A0A178V1N6, A0A384KTR9, Q5PNX9

Conserved Domains (1) summary

cd04133
Location:6 → 178

Rop_like; Rho-related protein from plants (Rop)-like
NM_119668.6 → NP_195228.1 RAC-like 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195228.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P92989, Q38912, Q84W42

UniProtKB/TrEMBL

A0A178V1N6, A0A384KTR9, Q5PNX9

Conserved Domains (1) summary

cd04133
Location:6 → 178

Rop_like; Rho-related protein from plants (Rop)-like
NM_001342314.1 → NP_001327973.1 RAC-like 3 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B372

Conserved Domains (1) summary

cl38936
Location:6 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases