Impact impact RWD domain protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Impactprovided by RGD
Official Full Name: impact RWD domain proteinprovided by RGD
Primary source: RGD:1591977
See related: EnsemblRapid:ENSRNOG00000045844 AllianceGenome:RGD:1591977
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity; protein sequestering activity; and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 814.8), Thymus (RPKM 267.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (4383546..4422280)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (4108872..4147571)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (4325872..4346734)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131046 (e-PCR)
- UniSTS:214329

RH143392 (e-PCR)
- UniSTS:232639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GCN2-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in GCN2-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in GCN2-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytoplasmic translational initiation in response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoplasmic translational initiation in response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein IMPACT

Names: imprinted and ancient gene protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012235.1 → NP_001012235.1 protein IMPACT

See identical proteins and their annotated locations for NP_001012235.1

Status: PROVISIONAL

Source sequence(s)

AY574213

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9

Related

ENSRNOP00000102236.1, ENSRNOT00000121832.1

Conserved Domains (2) summary

smart00591
Location:15 → 115

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam01205
Location:180 → 285

UPF0029; Uncharacterized protein family UPF0029

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

4383546..4422280

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277509.1 → XP_063133579.1 protein IMPACT isoform X1

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9
XM_063277511.1 → XP_063133581.1 protein IMPACT isoform X1

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9
XM_063277510.1 → XP_063133580.1 protein IMPACT isoform X1

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9
XM_063277512.1 → XP_063133582.1 protein IMPACT isoform X1

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9
XM_039097018.2 → XP_038952946.1 protein IMPACT isoform X1

UniProtKB/Swiss-Prot

Q5GFD9

UniProtKB/TrEMBL

A0A8L2QV96, A6KLS9

Related

ENSRNOP00000078372.1, ENSRNOT00000116602.2

Conserved Domains (2) summary

smart00591
Location:15 → 115

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam01205
Location:180 → 285

UPF0029; Uncharacterized protein family UPF0029