Spry2 sprouty RTK signaling antagonist 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spry2provided by RGD
Official Full Name: sprouty RTK signaling antagonist 2provided by RGD
Primary source: RGD:1311472
See related: EnsemblRapid:ENSRNOG00000010058 AllianceGenome:RGD:1311472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase binding activity; protein serine/threonine kinase activator activity; and ubiquitin-protein transferase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Predicted to be located in cytoskeleton; membrane; and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 76.8), Brain (RPKM 75.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (89106809..89111926, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (82692291..82697408, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (90172769..90177823, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2.
Title: Identification of key features required for efficient S-acylation and plasma membrane targeting of sprouty-2.
nuclear Spry2 acts as a molecular link which co-ordinates airway and vascular growth of the cardiopulmonary system.
Title: Regulation of vascular signalling by nuclear Sprouty2 in fetal lung epithelial cells: Implications for co-ordinated airway and vascular branching in lung development.
SPRY2 negatively regulates fibroblast growth factor-2.
Title: Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats.
CK1 activity and binding are necessary for SPRY2 inhibition of FGF-stimulated neurite outgrowth in PC12 cells
Title: Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.
Spry2 mRNA, protein, and tyrosination on D18 and D21 were significantly decreased in hypoplastic lungs with and without congenital diaphragmatic hernia.
Title: Spatiotemporal alterations in Sprouty-2 expression and tyrosine phosphorylation in nitrofen-induced pulmonary hypoplasia.
Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH.
Title: Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia.
A comparison the distribution of Sprouty-1 and Sprouty-2 proteins by immunohistochemistry in developing and adult rat lung.
Title: Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung.
Results imply that Sprouty2 is highly expressed in adult peripheral neurons and its down-regulation strongly promotes elongative axon growth by activation of the Ras/Raf/ERK pathway.
Title: Sprouty2 down-regulation promotes axon growth by adult sensory neurons.
Ability of Spry2 isoforms to inhibit neurite outgrowth in PC-12 cells correlates with the propensity of Spry isoforms to inhibit the Ras/ERK pathway in the context of fibroblast growth factor receptor signaling.
Title: A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.
PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation
Title: Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143991 (e-PCR)
- UniSTS:233237

RH44769 (e-PCR)
- UniSTS:40599

BQ201059 (e-PCR)
- UniSTS:260565

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bud elongation involved in lung branching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule end	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein sprouty homolog 2

Names: sprouty 2; sprouty homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012046.2 → NP_001012046.1 protein sprouty homolog 2

See identical proteins and their annotated locations for NP_001012046.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

Q5HZA2

Related

ENSRNOP00000013342.3, ENSRNOT00000013342.8

Conserved Domains (1) summary

pfam05210
Location:182 → 283

Sprouty; Sprouty protein (Spry)
NM_001393836.1 → NP_001380765.1 protein sprouty homolog 2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

Q5HZA2

Conserved Domains (1) summary

pfam05210
Location:182 → 283

Sprouty; Sprouty protein (Spry)