Gpm6a glycoprotein m6a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpm6aprovided by RGD
Official Full Name: glycoprotein m6aprovided by RGD
Primary source: RGD:631368
See related: EnsemblRapid:ENSRNOG00000010731 AllianceGenome:RGD:631368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: M6a
Summary: Enables calcium channel activity. Involved in positive regulation of filopodium assembly; regulation of synapse organization; and synapse assembly. Located in several cellular components, including filopodium; neuron projection; and neuronal cell body. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone membrane. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 2678.9) and Kidney (RPKM 105.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (43374385..43706461, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (36641282..36973377, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (39367697..39719292, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats.
Title: Role of miR-124-3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats.
Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons.
Title: Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons.
Overexpression of M6a is accompanied by an increase in spine density, particularly in mature spines.
Title: Evidence for a role of glycoprotein M6a in dendritic spine formation and synaptogenesis.
Formation of filopodia by membrane glycoprotein M6a (Gpm6a) requires actin regulator coronin-1a (Coro1a), known to regulate plasma membrane localization and activation of Rac1 and its downstream effector Pak1.
Title: Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin-1a, Rac1, and p21-activated kinase 1 (Pak1).
we analyzed the functional contribution of transmembrane domains (TMDs) of the neuronal membrane glycoprotein M6a
Title: Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains.
Gestational stress affected gpm6a gene expression in offspring likely through changes in methylation status and in posttranscriptional regulation by microRNAs
Title: Prenatal stress changes the glycoprotein GPM6A gene expression and induces epigenetic changes in rat offspring brain.
Association of neuronal M6a with cholesterol-rich lipid rafts is important for M6a glycoprotein's role in filopodia formation and signal propagation.
Title: Neuronal glycoprotein M6a induces filopodia formation via association with cholesterol-rich lipid rafts.
Data suggest that M6a is a key molecule for dendritic spine formation during development.
Title: Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation.
The present study shows that chronic stress also regulates expression of M6a, a glycoprotein which is localised in axonal membranes.
Title: Expression of the axonal membrane glycoprotein M6a is regulated by chronic stress.
M6a is an axonal component of glutamatergic neurons and that it is localized to distinct sites of the axonal plasma membrane of pyramidal and granule cells
Title: Glycoprotein M6a is present in glutamatergic axons in adult rat forebrain and cerebellum.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neural retina development	ISO Inferred from Sequence Orthology more info
involved_in neural retina development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonal growth cone	IBA Inferred from Biological aspect of Ancestor more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuronal membrane glycoprotein M6-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394533.1 → NP_001381462.1 neuronal membrane glycoprotein M6-a isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6APM4, A6JPG6

Related

ENSRNOP00000075962.1, ENSRNOT00000092971.3

Conserved Domains (1) summary

pfam01275
Location:3 → 236

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_001394534.1 → NP_001381463.1 neuronal membrane glycoprotein M6-a isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A1B0GWN8

Related

ENSRNOP00000075966.1, ENSRNOT00000092968.3

Conserved Domains (1) summary

pfam01275
Location:2 → 184

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
NM_178105.3 → NP_835206.1 neuronal membrane glycoprotein M6-a isoform 1

See identical proteins and their annotated locations for NP_835206.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q812E9

UniProtKB/TrEMBL

A0A8I6APM4

Related

ENSRNOP00000099582.1, ENSRNOT00000127343.1

Conserved Domains (1) summary

pfam01275
Location:14 → 247

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

43374385..43706461 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275414.1 → XP_063131484.1 neuronal membrane glycoprotein M6-a isoform X1

UniProtKB/TrEMBL

A0A8I6APM4

Related

ENSRNOP00000014312.5, ENSRNOT00000014312.9
XM_039094504.2 → XP_038950432.1 neuronal membrane glycoprotein M6-a isoform X2

UniProtKB/TrEMBL

A0A1B0GWN8

Conserved Domains (1) summary

pfam01275
Location:2 → 184

Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
XM_063275415.1 → XP_063131485.1 neuronal membrane glycoprotein M6-a isoform X2

UniProtKB/TrEMBL

A0A1B0GWN8