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    Cers6 ceramide synthase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cers6provided by RGD
    Official Full Name
    ceramide synthase 6provided by RGD
    Primary source
    RGD:1561599
    See related
    EnsemblRapid:ENSRNOG00000024595 AllianceGenome:RGD:1561599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lass6; RGD1561599
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Involved in oligodendrocyte development and positive regulation of oligodendrocyte apoptotic process. Predicted to be located in endoplasmic reticulum. Orthologous to human CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 255.0), Kidney (RPKM 125.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cers6 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (74038520..74287544)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (53630637..53879692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (55094240..55338370)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932414N04 gene like Neighboring gene uncharacterized LOC134486375 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 1 Neighboring gene uncharacterized LOC134486099 Neighboring gene Y box binding protein 1, pseudogene 9 Neighboring gene nitric oxide synthase trafficking Neighboring gene SPC25 component of NDC80 kinetochore complex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inactivation of ceramide synthase 6 in mice results in an altered sphingolipid metabolism and behavioral abnormalities. Ebel P, et al. J Biol Chem, 2013 Jul 19. PMID 23760501, Free PMC Article
    2. Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis. Novgorodov SA, et al. J Biol Chem, 2011 Feb 11. PMID 21148554, Free PMC Article
    3. A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity. Mesika A, et al. J Biol Chem, 2007 Sep 14. PMID 17609214
    4. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. Novgorodov SA, et al. J Biol Chem, 2016 Jan 22. PMID 26620563, Free PMC Article
    5. Mammalian Lass6 and its related family members regulate synthesis of specific ceramides. Mizutani Y, et al. Biochem J, 2005 Aug 15. PMID 15823095, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel role for CerS6 in the regulation of both mitochondrial Ca(2+) homeostasis and calpain, which appears to be important in OL apoptosis during brain development.
      Title: Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of oligodendrocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ceramide synthase 6
    Names
    LAG1 homolog, ceramide synthase 6
    LAG1 longevity assurance homolog 6
    NP_001386291.1
    NP_001386292.1
    XP_038962289.1
    XP_063140342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399362.1 → NP_001386291.1  ceramide synthase 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZL71, F1LTP8
      Related
      ENSRNOP00000055558.4, ENSRNOT00000058763.6
      Conserved Domains (2) summary
      cd00086
      Location:80 → 127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131 → 324
      TRAM_LAG1_CLN8; TLC domain

    2. NM_001399363.1 → NP_001386292.1  ceramide synthase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZL71, A0A8I6A742, A6HLZ6
      Related
      ENSRNOP00000088922.1, ENSRNOT00000111194.2
      Conserved Domains (2) summary
      cd00086
      Location:80 → 127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131 → 324
      TRAM_LAG1_CLN8; TLC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      74038520..74287544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106361.2 → XP_038962289.1  ceramide synthase 6 isoform X1

      Conserved Domains (2) summary
      cd00086
      Location:80 → 127
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam03798
      Location:131 → 282
      TRAM_LAG1_CLN8; TLC domain

    2. XM_063284272.1 → XP_063140342.1  ceramide synthase 6 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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