U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MPK3 mitogen-activated protein kinase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823706, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MPK3
    Official Full Name
    mitogen-activated protein kinase 3
    Primary source
    TAIR:AT3G45640
    Locus tag
    AT3G45640
    See related
    Araport:AT3G45640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMAPK3; ATMPK3; mitogen-activated protein kinase 3; T6D9.4
    Summary
    Encodes a mitogen-activated kinase whose mRNA levels increase in response to touch, cold, salinity stress and chitin oligomers.Also functions in ovule development. Heterozygous MPK3 mutants in a homozygous MPK6 background are female sterile due to defects in integument development. MPK3 can be dephosphorylated by MKP2 in vitro.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MPK3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (16756571..16758874)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene RNA binding (RRM/RBD/RNP motifs) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene nitrate excretion transporter1 Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Constitutive activity of the Arabidopsis MAP Kinase 3 confers resistance to Pseudomonas syringae and drives robust immune responses. Lang J, et al. Plant Signal Behav, 2017 Aug 3. PMID 28766995, Free PMC Article
    2. Functional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences. Frei dit Frey N, et al. Genome Biol, 2014 Jun 30. PMID 24980080, Free PMC Article
    3. Mitogen-activated protein kinase signaling in postgermination arrest of development by abscisic acid. Lu C, et al. Proc Natl Acad Sci U S A, 2002 Nov 26. PMID 12434021, Free PMC Article
    4. Guard cell-specific inhibition of Arabidopsis MPK3 expression causes abnormal stomatal responses to abscisic acid and hydrogen peroxide. Gudesblat GE, et al. New Phytol, 2007. PMID 17286820
    5. Expression pattern and core region analysis of AtMPK3 promoter in response to environmental stresses. Gao F, et al. Sci China Life Sci, 2010 Nov. PMID 21046323

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis G-protein beta subunit AGB1 represses abscisic acid signaling via attenuation of the MPK3-VIP1 phosphorylation cascade.
      Title: Arabidopsis G-protein β subunit AGB1 represses abscisic acid signaling via attenuation of the MPK3-VIP1 phosphorylation cascade.
    2. Dephosphorylation of the MAP kinases MPK6 and MPK3 fine-tunes responses to wounding and herbivory in Arabidopsis.
      Title: Dephosphorylation of the MAP kinases MPK6 and MPK3 fine-tunes responses to wounding and herbivory in Arabidopsis.
    3. MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
      Title: MITOGEN-ACTIVATED PROTEIN KINASE3 enhances disease resistance of edr1 mutants by phosphorylating MAPKKK5.
    4. MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.
      Title: MYB44 regulates PTI by promoting the expression of EIN2 and MPK3/6 in Arabidopsis.
    5. Interplay between glutathione and mitogen-activated protein kinase 3 via transcription factor WRKY40 under combined osmotic and cold stress in Arabidopsis.
      Title: Interplay between glutathione and mitogen-activated protein kinase 3 via transcription factor WRKY40 under combined osmotic and cold stress in Arabidopsis.
    6. Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
      Title: Phosphatidic acid modulates MPK3- and MPK6-mediated hypoxia signaling in Arabidopsis.
    7. AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity.
      Title: AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity.
    8. SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants.
      Title: SUMO enables substrate selectivity by mitogen-activated protein kinases to regulate immunity in plants.
    9. A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions.
      Title: A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions.
    10. SCREAM functions as a scaffold that recruits MPK3/6 to downregulate SPEECHLESS, a transcription factor that initiates stomatal cell lineages.
      Title: Bipartite anchoring of SCREAM enforces stomatal initiation by coupling MAP kinases to SPEECHLESS.
    Submit: New GeneRIF Correction See all GeneRIFs (59)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_114433.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within camalexin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflorescence development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen-pistil interaction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within priming of cellular response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal complex development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal complex patterning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to L-glutamate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to chitin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to freezing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mitogen-activated protein kinase 3
    NP_190150.1
    • mitogen-activated protein kinase 3 (MPK3); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), MAP kinase, conserved site (InterPro:IPR003527), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: MAP kinase 6 (TAIR:AT2G43790.1); Has 124285 Blast hits to 122929 proteins in 4636 species: Archae - 100; Bacteria - 13249; Metazoa - 47024; Fungi - 12588; Plants - 30092; Viruses - 485; Other Eukaryotes - 20747 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16756571..16758874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114433.3 → NP_190150.1  mitogen-activated protein kinase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39023, Q9M1E3
      UniProtKB/TrEMBL
      A0A178VFQ7, A0A384L050, A0A7G2EVE9, Q0WVS7
      Conserved Domains (1) summary
      cd07858
      Location:31 → 367
      STKc_TEY_MAPK; Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39023.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools