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    Mpv17l2 MPV17 mitochondrial inner membrane protein like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290645, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mpv17l2provided by RGD
    Official Full Name
    MPV17 mitochondrial inner membrane protein like 2provided by RGD
    Primary source
    RGD:1308064
    See related
    EnsemblRapid:ENSRNOG00000019394 AllianceGenome:RGD:1308064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308064
    Summary
    Predicted to be involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 166.5), Kidney (RPKM 122.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpv17l2 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18713690..18718191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18680106..18684212)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20432734..20435125)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482470 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene RAB3A, member RAS oncogene family Neighboring gene phosphodiesterase 4C Neighboring gene colon, intestine and stomach enriched 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MPV17L2 is required for ribosome assembly in mitochondria. Dalla Rosa I, et al. Nucleic Acids Res, 2014 Jul. PMID 24948607, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mpv17-like protein 2
    Names
    MPV17 mitochondrial membrane protein-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106072.3 → NP_001099542.1  mpv17-like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001099542.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6KA03, D4A9N8
      Related
      ENSRNOP00000026271.6, ENSRNOT00000026271.8
      Conserved Domains (1) summary
      pfam04117
      Location:124 → 186
      Mpv17_PMP22; Mpv17 / PMP22 family

    2. NM_001399440.1 → NP_001386369.1  mpv17-like protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Conserved Domains (1) summary
      pfam04117
      Location:122 → 183
      Mpv17_PMP22; Mpv17 / PMP22 family

    3. NM_001399441.1 → NP_001386370.1  mpv17-like protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Conserved Domains (1) summary
      pfam04117
      Location:58 → 119
      Mpv17_PMP22; Mpv17 / PMP22 family

    4. NM_001399443.1 → NP_001386372.1  mpv17-like protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Conserved Domains (1) summary
      pfam04117
      Location:58 → 119
      Mpv17_PMP22; Mpv17 / PMP22 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18713690..18718191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005494566.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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