Stambp Stam binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stambpprovided by RGD
Official Full Name: Stam binding proteinprovided by RGD
Primary source: RGD:619963
See related: EnsemblRapid:ENSRNOG00000012227 AllianceGenome:RGD:619963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Amsh
Summary: Predicted to enable K63-linked deubiquitinase activity and protein domain specific binding activity. Predicted to be involved in negative regulation of Ras protein signal transduction and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within mitotic cytokinesis; negative regulation of hippocampal neuron apoptotic process; and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cleavage furrow and endosome. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 37.2), Kidney (RPKM 27.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117613730..117642163, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (116055563..116083563, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (115249343..115277340, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulatory role of alpha-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.
Title: Modulatory role of α-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K63-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of hippocampal neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STAM-binding protein

Names: associated molecule with the SH3 domain of STAM

NP_612540.1

EC 3.1.2.15

XP_006236788.1

EC 3.1.2.15

XP_006236789.1

EC 3.1.2.15

XP_038962914.1

EC 3.1.2.15

XP_038962915.1

EC 3.1.2.15

XP_063141530.1

EC 3.1.2.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138531.2 → NP_612540.1 STAM-binding protein

See identical proteins and their annotated locations for NP_612540.1

Status: PROVISIONAL

Source sequence(s)

BC061711

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6

Related

ENSRNOP00000014708.3, ENSRNOT00000014708.7

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 115

USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

117613730..117642163 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236726.5 → XP_006236788.1 STAM-binding protein isoform X1

See identical proteins and their annotated locations for XP_006236788.1

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 115

USP8_dimer; USP8 dimerization domain
XM_039106986.2 → XP_038962914.1 STAM-binding protein isoform X1

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 115

USP8_dimer; USP8 dimerization domain
XM_039106987.2 → XP_038962915.1 STAM-binding protein isoform X1

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 115

USP8_dimer; USP8 dimerization domain
XM_006236727.5 → XP_006236789.1 STAM-binding protein isoform X1

See identical proteins and their annotated locations for XP_006236789.1

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 115

USP8_dimer; USP8 dimerization domain
XM_063285460.1 → XP_063141530.1 STAM-binding protein isoform X1

UniProtKB/Swiss-Prot

Q8R424

UniProtKB/TrEMBL

A6IAN4, A6IAN6