Cd55 CD55 molecule (Cromer blood group) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd55provided by RGD
Official Full Name: CD55 molecule (Cromer blood group)provided by RGD
Primary source: RGD:620651
See related: EnsemblRapid:ENSRNOG00000003927 AllianceGenome:RGD:620651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Daf; Daf1
Summary: Enables enzyme inhibitor activity. Involved in several processes, including maternal process involved in parturition; negative regulation of complement activation; and response to peptide hormone. Located in apical plasma membrane. Used to study neuroblastoma and proteinuria. Human ortholog(s) of this gene implicated in prostate cancer and protein-losing enteropathy. Orthologous to human CD55 (CD55 molecule (Cromer blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 104.8), Lung (RPKM 66.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (44409574..44438913, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (41857242..41885966, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47125156..47153557, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.
Title: Generation of a novel decay accelerating factor (DAF) knock-out rat model using clustered regularly-interspaced short palindromic repeats, (CRISPR)/associated protein 9 (Cas9), genome editing.
HO-1 is a physiologic regulator of glomerular decay accelerating factor (DAF) and identify hemin analogues as inducers of functional glomerular DAF able to minimize complement component C3 fragment b (C3b) deposition.
Title: Heme Oxygenase 1 Up-Regulates Glomerular Decay Accelerating Factor Expression and Minimizes Complement Deposition and Injury.
The increased expression of CD55 could be an important mechanism by which steroids help to reduce the cerebral damage caused by inflammation.
Title: Neurosteroids reduce inflammation after TBI through CD55 induction.
In rats, CD59 and DAF genes are related to the negative effect of sulfasalazine on sperm maturation.
Title: Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine.
In vivo, DAF is present on glomerular epithelial cells apical surfaces.
Title: Decay-accelerating factor expression in the rat kidney is restricted to the apical surface of podocytes.
Post-puberty, CD55 was expressed at high levels on all spermiogenic cells from step 6 spermatid onward, and on mature spermatozoa focussed on the acrosome, but was absent from support cells and early progenitors.
Title: CD55 in rat male reproductive tissue: differential expression in testis and expression of a unique truncated isoform on spermatozoa.

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General gene information

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Markers

RH141317 (e-PCR)
- UniSTS:223313

RH139453 (e-PCR)
- UniSTS:221539

RH132379 (e-PCR)
- UniSTS:215662

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in maternal process involved in parturition	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement decay-accelerating factor

Names: CD55 antigen; CD55 molecule, decay accelerating factor for complement; decay accelarating factor 1; decay accelerating factor 1; decay accelerating factor GPI-form; decay-accelarating factor; glycosylphophatidylinositol-anchored form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022269.2 → NP_071605.2 complement decay-accelerating factor precursor

See identical proteins and their annotated locations for NP_071605.2

Status: VALIDATED

Source sequence(s)

BC061869, CB610207

UniProtKB/TrEMBL

A0A0G2QC50, A0A9K3Y778, G3V6H8, Q9QUN6, Q9Z0M0

Related

ENSRNOP00000005284.7, ENSRNOT00000005284.8

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

44409574..44438913 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272578.1 → XP_063128648.1 complement decay-accelerating factor isoform X5

UniProtKB/TrEMBL

A9CMA5
XM_063272577.1 → XP_063128647.1 complement decay-accelerating factor isoform X3

UniProtKB/TrEMBL

Q9QUN6

Related

ENSRNOP00000079102.2, ENSRNOT00000097302.2
XM_063272579.1 → XP_063128649.1 complement decay-accelerating factor isoform X8

UniProtKB/TrEMBL

A6IBX9
XM_017598924.3 → XP_017454413.1 complement decay-accelerating factor isoform X10

UniProtKB/TrEMBL

A9CMA5
XM_006249723.5 → XP_006249785.1 complement decay-accelerating factor isoform X9

UniProtKB/TrEMBL

Q9QUN6

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)
XM_017598923.3 → XP_017454412.1 complement decay-accelerating factor isoform X4

UniProtKB/TrEMBL

A0A8I5ZMB7, A6IBX8, Q9QUN6

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)
XM_039091062.2 → XP_038946990.1 complement decay-accelerating factor isoform X6

UniProtKB/TrEMBL

Q9QUT3

Conserved Domains (2) summary

cd00033
Location:36 → 94

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:94 → 283

PHA02927; secreted complement-binding protein; Provisional
XM_006249719.5 → XP_006249781.1 complement decay-accelerating factor isoform X7

See identical proteins and their annotated locations for XP_006249781.1

UniProtKB/TrEMBL

A6IBY0, Q9QUT3

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)
XM_008769498.4 → XP_008767720.1 complement decay-accelerating factor isoform X11

UniProtKB/TrEMBL

Q9QUT3

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)
XM_063272576.1 → XP_063128646.1 complement decay-accelerating factor isoform X1
XM_006249717.5 → XP_006249779.1 complement decay-accelerating factor isoform X2

See identical proteins and their annotated locations for XP_006249779.1

UniProtKB/TrEMBL

Q9Z0L9

Conserved Domains (2) summary

cd00033
Location:225 → 284

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam00084
Location:98 → 158

Sushi; Sushi repeat (SCR repeat)