Sipa1l1 signal-induced proliferation-associated 1 like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sipa1l1provided by RGD
Official Full Name: signal-induced proliferation-associated 1 like 1provided by RGD
Primary source: RGD:708497
See related: EnsemblRapid:ENSRNOG00000007646 AllianceGenome:RGD:708497
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SPAL; Spa1; Spar; Spa-1
Summary: Enables actin filament binding activity; protein kinase binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including activation of GTPase activity; postsynaptic actin cytoskeleton organization; and regulation of postsynapse organization. Located in dendritic spine; neuronal cell body; and postsynaptic density. Part of protein-containing complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human SIPA1L1 (signal induced proliferation associated 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 163.0), Kidney (RPKM 136.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (107570569..107849613)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (101839351..102118408)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (106052212..106163249)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The microwave radiation led to shrinkage and even loss of dendritic spines in hippocampus by SNK-SPAR pathway, resulting in the cognitive impairments.
Title: Microwave radiation leading to shrinkage of dendritic spines in hippocampal neurons mediated by SNK-SPAR pathway.
Prenatal stress increased spar in thr hippocampus of the offspring at adulthood in rats
Title: Prenatal stress increased Snk Polo-like kinase 2, SCF β-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.
Long-term potentiation triggers downregulation of SPAR requiring ubiquitin proteasome system and NMDA receptor activation but not cyclin-dependent kinase (CDK)5.
Title: Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons.
the SNK-SPAR pathway may possibly play a crucial role in Amyloid beta-induced excitotoxic damage in the central nervous system by regulating synaptic stability.
Title: Role of the SNK-SPAR pathway in the development of Alzheimer's disease.
the multiple SPAR functional domains have been expressed in E. coli in quantities suitable for biophysical and biochemical studies, allowing us to investigate the role of the PDZ domain in SPAR function .
Title: Heterologous high-level E. coli expression, purification and biophysical characterization of the spine-associated RapGAP (SPAR) PDZ domain.
postsynaptic RapGAP SPAR is regulated by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons
Title: Regulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neurons.
serum-inducible kinase bound to and phosphorylated spine-associated Rap guanosine triphosphatase activating protein (SPAR), a postsynaptic actin regulatory protein, leading to degradation of SPAR
Title: Targeted protein degradation and synapse remodeling by an inducible protein kinase.
findings suggest that SPAL may be involved in the NMDA-mediated organization of cytoskeletal networks and signal transduction
Title: SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus.
PSD-Zip70 in collaboration with SPAR is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity.
Title: Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity.
SPA-1 directly binds to AQP2 and regulates at least in part AQP2 trafficking
Title: Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138739 (e-PCR)
- UniSTS:220826

ksks223 (e-PCR)
- UniSTS:514257

BE116899 (e-PCR)
- UniSTS:248562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal-induced proliferation-associated 1-like protein 1

Names: SIPA1-like protein 1; SPA-1 like protein; SPA-1-like protein p1294; spine-associated Rap GTPase-activating protein; spine-associated Rap guanosine triphosphatase (GTPase) activating protein (GAP)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389245.1 → NP_001376174.1 signal-induced proliferation-associated 1-like protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6JDP1, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1715 → 1770

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1727

SPAR_C; C-terminal domain of SPAR protein
NM_139330.2 → NP_647546.2 signal-induced proliferation-associated 1-like protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Related

ENSRNOP00000109852.1, ENSRNOT00000168984.1

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

107570569..107849613

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111779.2 → XP_038967707.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein
XM_063261545.1 → XP_063117615.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65
XM_039111778.2 → XP_038967706.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein
XM_063261546.1 → XP_063117616.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65
XM_039111780.2 → XP_038967708.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein
XM_063261550.1 → XP_063117620.1 signal-induced proliferation-associated 1-like protein 1 isoform X5
XM_039111776.2 → XP_038967704.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein
XM_063261547.1 → XP_063117617.1 signal-induced proliferation-associated 1-like protein 1 isoform X2

UniProtKB/TrEMBL

A6JDP1, F1LS65
XM_063261548.1 → XP_063117618.1 signal-induced proliferation-associated 1-like protein 1 isoform X3

UniProtKB/TrEMBL

F1LS65
XM_063261549.1 → XP_063117619.1 signal-induced proliferation-associated 1-like protein 1 isoform X4

UniProtKB/TrEMBL

F1LS65

Related

ENSRNOP00000075549.3, ENSRNOT00000088917.3
XM_039111781.2 → XP_038967709.1 signal-induced proliferation-associated 1-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2KAW2, F1LS65

Conserved Domains (4) summary

cd00992
Location:953 → 1023

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:629 → 809

Rap_GAP; Rap/ran-GAP

pfam06005
Location:1716 → 1771

ZapB; Cell division protein ZapB

pfam11881
Location:1483 → 1728

SPAR_C; C-terminal domain of SPAR protein