Htr1f 5-hydroxytryptamine receptor 1F [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Htr1fprovided by RGD
Official Full Name: 5-hydroxytryptamine receptor 1Fprovided by RGD
Primary source: RGD:71083
See related: EnsemblRapid:ENSRNOG00000000716 AllianceGenome:RGD:71083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Htr1eb
Summary: Predicted to enable neurotransmitter receptor activity; serotonin binding activity; and transmembrane signaling receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to be located in synapse. Predicted to be active in dendrite and plasma membrane. Orthologous to human HTR1F (5-hydroxytryptamine receptor 1F). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 11p12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (16089266..16090665, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (2642751..2644150, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (1982113..1983513, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in 5-HT1F receptor expression in rats with spasticity following spinal cord injury.
Title: Changes in 5-HT1F receptor expression in rats with spasticity following spinal cord injury.
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury are regulated by 5-HT1F and 5-HT1B receptors.
Title: Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
5-HT(1B), 5-HT(1D)and 5-HT(1F) receptor expression are equally represented in trigeminal ganglia and the dorsal root ganglia.
Title: Distribution of 5-HT(1B), 5-HT(1D) and 5-HT(1F) receptor expression in rat trigeminal and dorsal root ganglia neurons: relevance to the selective anti-migraine effect of triptans.
This study demonstrates the colocalization of 5-HT(1F) receptor and CGRP in the rat vestibular nuclei, indicates that 5-HT(1F) receptor agonists may ameliorate migrainous vertigo by attenuating elevated levels of CGRP release from vestibular nuclei.
Title: Colocalization of 5-HT1F receptor and calcitonin gene-related peptide in rat vestibular nuclei.
colocalization of 5-HT1F receptor and glutamate in the vestibular nuclei wsas observed; this suggests that 5-HT1F receptor might modulate glutamate release from the vestibular nuclei
Title: Colocalization of 5-HT1F receptor and glutamate in neurons of the vestibular nuclei in rats.

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General gene information

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Markers

Htr1f (e-PCR), detects polymorphism
- UniSTS:143419

Htr1f (e-PCR), detects polymorphism
- UniSTS:143420

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables Gi/o-coupled serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables Gi/o-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IEA Inferred from Electronic Annotation more info
enables serotonin binding	ISO Inferred from Sequence Orthology more info
enables serotonin receptor activity	IEA Inferred from Electronic Annotation more info
enables serotonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1F

Names: 5-HT-1F; 5-HT1F; 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled; serotonin receptor 1F; serotonin receptor gene (similar to Mm Htr1eb)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021857.4 → NP_068629.2 5-hydroxytryptamine receptor 1F

See identical proteins and their annotated locations for NP_068629.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P30940

UniProtKB/TrEMBL

A6K4W3, G3V626

Related

ENSRNOP00000000907.3, ENSRNOT00000000907.7

Conserved Domains (2) summary

pfam00001
Location:41 → 347

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:41 → 222

7tm_4; Olfactory receptor