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    Sebox SEBOX homeobox [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Seboxprovided by RGD
    Official Full Name
    SEBOX homeoboxprovided by RGD
    Primary source
    RGD:62077
    See related
    EnsemblRapid:ENSRNOG00000009979 AllianceGenome:RGD:62077
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Og9x
    Summary
    Predicted to enable DNA binding activity. Predicted to act upstream of or within embryo development and oogenesis. Predicted to be located in nucleus. Orthologous to human SEBOX (SEBOX homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 11.2), Thymus (RPKM 2.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sebox in Genome Data Viewer
    Location:
    10q25
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63897265..63898136)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63399215..63400086)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65771370..65774748)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sterile alpha and TIR motif containing 1 Neighboring gene vitronectin Neighboring gene transmembrane protein 199 Neighboring gene DNA polymerase delta interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sebox plays an important role during the early mouse oogenesis in vitro. Moreno DL, et al. Zygote, 2014 Feb. PMID 22805237
    2. Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. Cinquanta M, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922053, Free PMC Article
    3. SEBOX is essential for early embryogenesis at the two-cell stage in the mouse. Kim KH, et al. Biol Reprod, 2008 Dec. PMID 18753614
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in birth or egg hatching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein SEBOX
    Names
    OG9 homeobox
    homeobox OG-9
    skin-, embryo-, brain- and oocyte-specific homeobox

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023951.1 → NP_076441.1  homeobox protein SEBOX

      See identical proteins and their annotated locations for NP_076441.1

      Status: PROVISIONAL

      Source sequence(s)
      AF284338
      UniProtKB/Swiss-Prot
      Q9ERS8
      UniProtKB/TrEMBL
      A6HH55, G3V797
      Related
      ENSRNOP00000013296.1, ENSRNOT00000013296.4
      Conserved Domains (2) summary
      COG5576
      Location:13 → 121
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:21 → 72
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63897265..63898136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERS8.1 GenPept UniProtKB/Swiss-Prot:Q9ERS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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