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    Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpn12provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 12provided by RGD
    Primary source
    RGD:620894
    See related
    EnsemblRapid:ENSRNOG00000013135 AllianceGenome:RGD:620894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptpg1; RKPTP
    Summary
    Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 148.8), Spleen (RPKM 103.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn12 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14913071..14985084)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (14020997..14092931)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10631129..10702390)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC102556034 Neighboring gene uncharacterized LOC120102213 Neighboring gene round spermatid basic protein 1-like Neighboring gene Alu-mediated CDKN1A/p21 transcriptional regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney. Moriyama T, et al. FEBS Lett, 1994 Oct 24. PMID 7957881
    2. ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin. Gorostizaga AB, et al. J Cell Biochem, 2016 Sep. PMID 27061092
    3. Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners. Motohashi S, et al. Cell Immunol, 2014 May-Jun. PMID 24791697
    4. Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase. Charest A, et al. Biochem J, 1995 Jun 1. PMID 7772023, Free PMC Article
    5. Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas. Ceacareanu AC, et al. Am J Physiol Cell Physiol, 2006 Apr. PMID 16354758

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction
      Title: ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
    2. PTP-PEST is involved in the regulation of FcepsilonRI-mediated mast cell activation through at least two different processes represented by PTP activity-dependent and -independent pathways.
      Title: Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
    3. Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST
      Title: Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 12
    NP_476456.2
    XP_006235930.1
    XP_006235932.1
    XP_063141493.1
    XP_063141494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057115.2 → NP_476456.2  tyrosine-protein phosphatase non-receptor type 12

      See identical proteins and their annotated locations for NP_476456.2

      Status: VALIDATED

      Source sequence(s)
      BP489229, CK367675, CV102923, CX570435, D38072, DY560717
      UniProtKB/TrEMBL
      A0A8I5ZN71, A6K5C4, G3V7Q4
      Related
      ENSRNOP00000079518.1, ENSRNOT00000106350.2
      Conserved Domains (2) summary
      smart00194
      Location:28 → 292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60 → 292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14913071..14985084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235868.5 → XP_006235930.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN71
      Related
      ENSRNOP00000102951.1, ENSRNOT00000122000.1
      Conserved Domains (2) summary
      smart00194
      Location:28 → 292
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:60 → 292
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_063285423.1 → XP_063141493.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN71
      Related
      ENSRNOP00000017907.6, ENSRNOT00000017907.7

    3. XM_006235870.3 → XP_006235932.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN71
      Conserved Domains (2) summary
      cd00047
      Location:1 → 173
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:1 → 173
      Y_phosphatase; Protein-tyrosine phosphatase

    4. XM_063285424.1 → XP_063141494.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN71
      Related
      ENSRNOP00000111147.1, ENSRNOT00000126039.1
    Nucleotide Protein Strain
    Heading Accession and Version

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