Unc5a unc-5 netrin receptor A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc5aprovided by RGD
Official Full Name: unc-5 netrin receptor Aprovided by RGD
Primary source: RGD:621755
See related: EnsemblRapid:ENSRNOG00000059840 AllianceGenome:RGD:621755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Unc5h1
Summary: Enables netrin receptor activity. Involved in axon guidance and netrin-activated signaling pathway. Located in neuron projection membrane and neuronal cell body membrane. Orthologous to human UNC5A (unc-5 netrin receptor A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 33.6), Adrenal (RPKM 7.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9620005..9675794, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9614841..9670558, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (10152949..10208599, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unc5H Receptors have Prominent Expression in Adult Schwann cells.
Title: Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2.
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
Title: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
Hyperactivity increases the surface expression of uncoordinated-5A (Unc5a), which is suppressed by blocking cyclic adenosine monophosphate signaling.
Title: The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
Surface expression of the netrin receptor UNC5H1 is regulated by Protein interacting with C kinase-1 and protein kinase C in neurons.
Title: Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism.
UNC5H1 expression colocalised with a number of cranial motor neuron subpopulations from embryonic day 11 (E11) to E14.
Title: Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132669 (e-PCR)
- UniSTS:215952

Unc5a (e-PCR), detects polymorphism
- UniSTS:532695

BF416660 (e-PCR)
- UniSTS:249331

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables netrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axon guidance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in neuron projection membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in neuronal cell body membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: netrin receptor UNC5A

Names: protein unc-5 homolog 1; protein unc-5 homolog A; transmembrane receptor Unc5H1; unc-5 homolog 1; unc-5 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022206.2 → NP_071542.2 netrin receptor UNC5A precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

O08721

UniProtKB/TrEMBL

A0A8I5YBB0

Related

ENSRNOP00000076444.2, ENSRNOT00000107999.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

9620005..9675794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771505.3 → XP_008769727.1 netrin receptor UNC5A isoform X1

UniProtKB/Swiss-Prot

O08721

UniProtKB/TrEMBL

A0A0G2JZN2

Related

ENSRNOP00000071115.3, ENSRNOT00000087397.3

Conserved Domains (5) summary

smart00218
Location:439 → 542

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

smart00209
Location:254 → 293

TSP1; Thrombospondin type 1 repeats

pfam07679
Location:151 → 239

I-set; Immunoglobulin I-set domain

cd08800
Location:755 → 838

Death_UNC5A; Death domain found in Uncoordinated-5A

cl11960
Location:153 → 239

Ig; Immunoglobulin domain