Map3k12 mitogen activated protein kinase kinase kinase 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map3k12provided by RGD
Official Full Name: mitogen activated protein kinase kinase kinase 12provided by RGD
Primary source: RGD:3988
See related: EnsemblRapid:ENSRNOG00000015134 AllianceGenome:RGD:3988
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PK; DLK; MUK; Zpk
Summary: Predicted to enable several functions, including JUN kinase kinase kinase activity; protein homodimerization activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including JNK cascade; positive regulation of MAPK cascade; and protein phosphorylation. Predicted to act upstream of or within negative regulation of motor neuron apoptotic process. Predicted to be located in cytosol; growth cone; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 109.7), Lung (RPKM 56.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135507082..135527396, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133630267..133648464, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144102275..144120306, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development.
Title: The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development.
These findings explain how DLK specifically mediates nerve injury responses and reveal a novel cellular mechanism that ensures the specificity of neuronal kinase signaling.
Title: Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.
DLK is required for RGC JNK activation and cell death in a rodent model of optic neuropathy
Title: Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
Src-dependent tyrosine phosphorylation of recombinant rat DLK was important for regulation of its activity. DLK may have a role in PDGF signaling.
Title: The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF).
Dlk is expressed in a subpopulation of oval cells and that Dlk(+) cells represent intermediate cells between Dlk(-) oval cells and mature hepatocytes.
Title: Expression of Dlk/Pref-1 defines a subpopulation in the oval cell compartment of rat liver.
MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in developing mouse telencephalon during radial migration
Title: MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC87148P1 (e-PCR)
- UniSTS:273582

AA924752 (e-PCR)
- UniSTS:248250

AA924752 (e-PCR)
- UniSTS:261821

RH134302 (e-PCR)
- UniSTS:217584

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of macromolecule metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 12

Names: MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); Zipper (leucine) protein kinase; dual leucine zipper bearing kinase; dual leucine zipper kinase; leucine-zipper protein kinase; mixed lineage kinase

NP_037187.1

EC 2.7.11.25

XP_006242443.1

EC 2.7.11.25

XP_006242444.1

EC 2.7.11.25

XP_063119102.1

EC 2.7.11.25

XP_063119104.1

EC 2.7.11.25

XP_063119105.1

EC 2.7.11.25

XP_063119106.1

EC 2.7.11.25

XP_063119107.1

EC 2.7.11.25

XP_063119108.1

EC 2.7.11.25

XP_063119109.1

EC 2.7.11.25

XP_063119110.1

EC 2.7.11.25

XP_063119111.1

EC 2.7.11.25

XP_063119112.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013055.1 → NP_037187.1 mitogen-activated protein kinase kinase kinase 12

See identical proteins and their annotated locations for NP_037187.1

Status: PROVISIONAL

Source sequence(s)

D49785

UniProtKB/Swiss-Prot

Q63796

UniProtKB/TrEMBL

A0A8I6AF79

Related

ENSRNOP00000020437.4, ENSRNOT00000020437.7

Conserved Domains (2) summary

smart00219
Location:165 → 397

TyrKc; Tyrosine kinase, catalytic domain

cd14059
Location:164 → 400

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

135507082..135527396 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263035.1 → XP_063119105.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263034.1 → XP_063119104.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263041.1 → XP_063119111.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_006242382.5 → XP_006242444.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

See identical proteins and their annotated locations for XP_006242444.1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89

Conserved Domains (1) summary

cd14059
Location:164 → 400

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_063263037.1 → XP_063119107.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263038.1 → XP_063119108.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263032.1 → XP_063119102.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263039.1 → XP_063119109.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263036.1 → XP_063119106.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_006242381.5 → XP_006242443.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

See identical proteins and their annotated locations for XP_006242443.1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89

Conserved Domains (1) summary

cd14059
Location:164 → 400

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
XM_063263040.1 → XP_063119110.1 mitogen-activated protein kinase kinase kinase 12 isoform X1

UniProtKB/TrEMBL

A0A8I6AF79, F1LQ89
XM_063263042.1 → XP_063119112.1 mitogen-activated protein kinase kinase kinase 12 isoform X2