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    Mrs2 magnesium transporter MRS2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrs2provided by RGD
    Official Full Name
    magnesium transporter MRS2provided by RGD
    Primary source
    RGD:708529
    See related
    EnsemblRapid:ENSRNOG00000017545 AllianceGenome:RGD:708529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rpt; Mrs2l
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Involved in lactate metabolic process. Located in mitochondrial inner membrane. Used to study demyelinating disease. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 131.4), Heart (RPKM 129.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrs2 in Genome Data Viewer
    Location:
    17p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (40491963..40515116)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40063924..40087073)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42064271..42083602)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482709 Neighboring gene doublecortin domain containing 2 Neighboring gene ribosomal protein L32, pseudogene 10 Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family, member A1 Neighboring gene KIAA0319 homolog Neighboring gene ribosomal protein L37, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect. Kuwamura M, et al. Brain Res, 2019 Sep 1. PMID 31100216
    2. A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat. Kuramoto T, et al. PLoS Genet, 2011 Jan 6. PMID 21253565, Free PMC Article
    3. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. Piskacek M, et al. J Cell Mol Med, 2009 Apr. PMID 18384665, Free PMC Article
    4. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Zsurka G, et al. Genomics, 2001 Mar 1. PMID 11401429
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.
      Title: Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.
    2. transgenic rats showed that MRS2 was dominantly expressed in neurons rather than oligodendrocytes and was ultrastructurally observed in the inner membrane of mitochondria
      Title: A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93415

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial magnesium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter MRS2 homolog, mitochondrial
    Names
    MRS2 magnesium homeostasis factor homolog
    MRS2 magnesium transporter
    MRS2-like protein
    MRS2-like, magnesium homeostasis factor
    RPT protein similar to yeast MRS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024001.1 → NP_076491.1  magnesium transporter MRS2 homolog, mitochondrial precursor

      See identical proteins and their annotated locations for NP_076491.1

      Status: PROVISIONAL

      Source sequence(s)
      AF288289
      UniProtKB/Swiss-Prot
      Q4FZY6, Q5XIW5, Q9ET07, Q9ET08, Q9ET09
      UniProtKB/TrEMBL
      A0A8I6A5Y1, A6KLE4
      Related
      ENSRNOP00000023787.5, ENSRNOT00000023787.7
      Conserved Domains (1) summary
      cd12823
      Location:79 → 390
      Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      40491963..40515116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253937.5 → XP_006253999.1  magnesium transporter MRS2 homolog, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5Y1
      Conserved Domains (1) summary
      cd12823
      Location:79 → 390
      Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

    2. XM_039096094.2 → XP_038952022.1  magnesium transporter MRS2 homolog, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl00459
      Location:79 → 249
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    RNA

    1. XR_010058955.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ET09.1 GenPept UniProtKB/Swiss-Prot:Q9ET09

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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