Rnpep arginyl aminopeptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnpepprovided by RGD
Official Full Name: arginyl aminopeptidaseprovided by RGD
Primary source: RGD:621137
See related: EnsemblRapid:ENSRNOG00000006720 AllianceGenome:RGD:621137
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 140.6), Testes (RPKM 139.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (49251259..49271440, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (46699458..46717829, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (52092863..52124006, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A structural analysis using circular dichroism, fluorescence spectroscopy, molecular modelling and dynamics was performed to investigate the role that residue G(298) plays in the catalytic mechanism of Ap-B
Title: Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties.
Results suggest that the upregulation of serotonergic activity may be related to a lowered brain dipeptidyl peptidase III, alanyl- and arginyl aminopeptidase activity which may have an influence on the cleavage of their physiological substrates.
Title: Central aminopeptidase and serotonin system activities: possible relationship.
Zinc regulation demonstrates the metallopeptidase property of AP-B.
Title: Zinc regulation of aminopeptidase B involved in neuropeptide production.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rnpep (e-PCR), detects polymorphism
- UniSTS:479250

BF386633 (e-PCR)
- UniSTS:243801

D13Hmgc24 (e-PCR)
- UniSTS:518008

BF400237 (e-PCR)
- UniSTS:244896

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cobalt ion binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloaminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	NAS Non-traceable Author Statement more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IC Inferred by Curator more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	NAS Non-traceable Author Statement more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aminopeptidase B

Names: AP-B; arginine aminopeptidase; cytosol aminopeptidase IV

NP_112359.2

EC 3.4.11.6

XP_063128706.1

EC 3.4.11.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429661.1 → NP_001416590.1 aminopeptidase B isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6GJU0, Q6P7D2
NM_031097.2 → NP_112359.2 aminopeptidase B isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6ICE6, G3V6V1, Q6P7D2

Related

ENSRNOP00000009198.3, ENSRNOT00000009198.7

Conserved Domains (2) summary

cd09599
Location:24 → 484

M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain

pfam09127
Location:530 → 645

Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal